{"id":"W2088549564","doi":"10.1242/jcs.128769","title":"Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks","year":2013,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; DNA damage; Chromatin; DNA; DNA repair; Cell biology; Molecular biology; Ku80; Poly ADP ribose polymerase; Genetics; DNA-binding protein; Gene; Polymerase; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002324217,0.000145337,0.0003395838,0.0002922459,0.0001159136,0.0001061956,0.0006275662,0.00005041013,0.0002696753],"category_scores_gemma":[0.0001308036,0.00009650843,0.00007751463,0.0008182064,0.000514004,0.0009039252,0.000018261,0.0003089868,0.000006412874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094086,"about_ca_system_score_gemma":0.0004256408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003653736,"about_ca_topic_score_gemma":0.00006107327,"domain_scores_codex":[0.9975901,0.0001343598,0.0005700677,0.0002431736,0.001096916,0.00036534],"domain_scores_gemma":[0.9984418,0.0002466056,0.0003315629,0.0003394039,0.0003855346,0.0002551448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001554051,0.0002765871,0.0009067651,0.00003955037,0.000003871623,0.00009112965,0.003591359,0.00007222702,0.9935852,0.00001799345,0.0001622924,0.001097572],"study_design_scores_gemma":[0.00118544,0.001174259,0.03184122,0.000508382,0.00001201183,0.000204719,0.001384628,0.00005839783,0.9628218,0.0004693416,0.000222088,0.00011765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924314,0.0001710104,0.000739529,0.002075624,0.0001208485,0.0004040864,0.000006135147,0.000007223457,0.004044126],"genre_scores_gemma":[0.9952506,0.00002980684,0.003602407,0.0009066745,0.00009301457,0.000007979374,4.809459e-7,0.00001034757,0.0000986996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03093445,"threshold_uncertainty_score":0.39355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890414107862374,"score_gpt":0.2926823388939917,"score_spread":0.263778197815368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}