{"id":"W2088556991","doi":"10.1016/j.bmcl.2011.08.069","title":"Selectivity of 3′-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Sucrase; Maltase; Enzyme; Hydrolysis; Selectivity; Biochemistry; Hydrolase; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867304,0.0002483676,0.0001543192,0.00009023461,0.0001079236,0.0001804451,0.0003267004,0.000339366,0.002373745],"category_scores_gemma":[0.0001561733,0.0001454374,0.0001792717,0.00007977846,0.0001318002,0.0002567177,0.0001248198,0.0003697895,0.0007228195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662023,"about_ca_system_score_gemma":0.0001721856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005381831,"about_ca_topic_score_gemma":0.0005976696,"domain_scores_codex":[0.9999079,0.00002152613,0.000004425093,0.0000193225,0.00001402756,0.00003283939],"domain_scores_gemma":[0.9999471,0.00002091681,0.000008755788,0.00000568729,0.000007591551,0.000009972665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003323381,0.00001975982,0.00005987796,0.00002215183,0.000003107119,0.0000417625,0.000008893226,0.00008812771,0.9967416,0.0001866446,0.0000556574,0.002440154],"study_design_scores_gemma":[0.00003431156,0.0004215463,0.0005447274,0.000003036506,0.00000690947,0.0002135909,0.000007377728,0.0005139442,0.9964096,0.00004772884,0.001792952,0.000004194316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983936,0.002582835,0.004988717,0.0001718512,0.00006730097,0.00004706854,0.0002749872,0.0001031402,0.007828119],"genre_scores_gemma":[0.9942847,0.001032386,0.001451456,0.0001074974,0.00001661511,0.00002085112,0.0002570732,0.00001831089,0.002811105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002373745,"threshold_uncertainty_score":0.007941008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952629565757957,"score_gpt":0.2536547060130927,"score_spread":0.2341284103555131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}