{"id":"W2088556991","doi":"10.1016/j.bmcl.2011.08.069","title":"Selectivity of 3′-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Sucrase; Maltase; Enzyme; Hydrolysis; Selectivity; Biochemistry; Hydrolase; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002866141,0.0002355205,0.0003183286,0.00003625878,0.00008680285,0.000004846411,0.00008404041,0.000225046,0.000009740234],"category_scores_gemma":[0.00008947388,0.0001821797,0.00008078933,0.00008454173,0.000421935,0.000007169497,0.00004197598,0.0001009913,1.000427e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001952903,"about_ca_system_score_gemma":0.0001693222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004180126,"about_ca_topic_score_gemma":0.00001068874,"domain_scores_codex":[0.9988326,0.0000467972,0.0003554723,0.0003839386,0.0001092814,0.000271882],"domain_scores_gemma":[0.9992277,0.00006788583,0.0002821221,0.0001739959,0.0001217727,0.0001265063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00179235,0.0001383403,0.001305838,0.0009684154,0.0001480035,0.00000570663,0.0003053901,6.606546e-7,0.992928,0.000006530931,0.0001048134,0.002295899],"study_design_scores_gemma":[0.002516856,0.0009053717,0.003591384,0.0001393858,0.0001944529,0.0001089669,0.0004385718,0.00006646919,0.9915166,0.00004762172,0.0002583932,0.0002158658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932871,0.0008682481,0.004404649,0.0003498074,0.00005536331,0.0006183206,0.0003798836,0.00000934053,0.00002721615],"genre_scores_gemma":[0.9985776,0.0002294501,0.0006142362,0.0001976358,0.0001280399,0.0000413562,0.0001532061,0.00003044798,0.0000280593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005290397,"threshold_uncertainty_score":0.7429075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952629565757957,"score_gpt":0.2536547060130927,"score_spread":0.2341284103555131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}