{"id":"W2088558054","doi":"10.1016/j.bmcl.2007.03.058","title":"Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Glutathione; Covalent bond; Glucuronide; In vitro; Indole test; In vivo; Biochemistry; Microsome; Stereochemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002522897,0.0002706502,0.0001651253,0.00008376576,0.0001739698,0.0001702488,0.0002900405,0.0002661361,0.001370617],"category_scores_gemma":[0.000228445,0.0001238798,0.0001956435,0.00009447027,0.0001607108,0.0002236052,0.0001930671,0.0002559508,0.000250318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184765,"about_ca_system_score_gemma":0.0001700833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000390024,"about_ca_topic_score_gemma":0.001052107,"domain_scores_codex":[0.9998573,0.00005163548,0.000007534053,0.00002055972,0.0000178473,0.00004510961],"domain_scores_gemma":[0.9999329,0.00001689267,0.0000224058,0.00001147005,0.000008496501,0.000007843903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007694072,0.00007464526,0.0003216375,0.00007142073,0.0000295289,0.000118621,0.00006515694,0.0003826934,0.9893043,0.001106378,0.0001975308,0.00755867],"study_design_scores_gemma":[0.00002161803,0.0003580081,0.0003305918,0.000002654718,0.00001392757,0.00007430456,0.00001087149,0.0004353342,0.9972481,0.00004554991,0.001454698,0.000004291047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900427,0.0009542826,0.005725021,0.0001635723,0.00003646173,0.00004297086,0.00008457362,0.00006863463,0.002881747],"genre_scores_gemma":[0.996749,0.0003789027,0.001291706,0.00005183572,0.000006100751,0.00001604513,0.00008311898,0.00001142226,0.001411977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370617,"threshold_uncertainty_score":0.004585147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082283517622439,"score_gpt":0.249542578887837,"score_spread":0.2387197437116126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}