{"id":"W2088569000","doi":"10.1158/1535-7163.targ-11-b155","title":"Abstract B155: A phase I study of the MEK inhibitor GSK1120212 (GSK212) in combination with PI3K/mTOR inhibitor GSK2126458 (GSK458) in patients with advanced solid tumors.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Tolerability; Pharmacodynamics; Medicine; Pharmacokinetics; Dosing; Pharmacology; PI3K/AKT/mTOR pathway; Toxicity; Kinase; Adverse effect; Internal medicine; Oncology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000151031,0.0003377695,0.0003644794,0.0001142278,0.0000580285,0.00002171929,0.0003376118,0.0001301705,0.00001388969],"category_scores_gemma":[0.00001908969,0.0002553616,0.00007224771,0.0003920511,0.0001305589,0.00001521822,0.0001150049,0.0002359093,7.969771e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235652,"about_ca_system_score_gemma":0.0002871747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002782554,"about_ca_topic_score_gemma":0.001982064,"domain_scores_codex":[0.9981546,0.000088436,0.0004708736,0.0005107434,0.0003965173,0.0003787872],"domain_scores_gemma":[0.9987161,0.00001685955,0.000338132,0.0006203339,0.0002341656,0.0000744494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01206628,0.01807668,0.5246233,0.0001667101,0.0006917579,0.0000891207,0.006169891,0.002798517,0.4111865,0.0001246842,0.0000571797,0.02394943],"study_design_scores_gemma":[0.03569854,0.009427928,0.4125137,0.0003446236,0.0001808979,0.000002403494,0.001221142,0.0000879272,0.5387511,0.00008850446,0.0008116779,0.0008715488],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974819,0.0005844649,0.000117546,0.00005535009,0.0001778193,0.001377141,0.00006088959,0.000008144707,0.000136687],"genre_scores_gemma":[0.9990058,0.00008067975,0.0001916356,0.0003477864,0.00004505649,0.0001994869,0.00003978485,0.00007455562,0.00001519279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1275647,"threshold_uncertainty_score":0.9999899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201470129370196,"score_gpt":0.2567090049202371,"score_spread":0.2446943036265351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}