{"id":"W2088569000","doi":"10.1158/1535-7163.targ-11-b155","title":"Abstract B155: A phase I study of the MEK inhibitor GSK1120212 (GSK212) in combination with PI3K/mTOR inhibitor GSK2126458 (GSK458) in patients with advanced solid tumors.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Tolerability; Pharmacodynamics; Medicine; Pharmacokinetics; Dosing; Pharmacology; PI3K/AKT/mTOR pathway; Toxicity; Kinase; Adverse effect; Internal medicine; Oncology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009830872,0.001582477,0.001526034,0.0005149544,0.0003836308,0.0009400303,0.0009364942,0.001041254,0.005264317],"category_scores_gemma":[0.0004933045,0.0005962075,0.001169805,0.0004340275,0.0006853222,0.0007446979,0.0003161131,0.002480719,0.001675451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008306669,"about_ca_system_score_gemma":0.001528906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332495,"about_ca_topic_score_gemma":0.002869066,"domain_scores_codex":[0.9997253,0.000105136,0.00002255001,0.00005978553,0.00003440168,0.00005284852],"domain_scores_gemma":[0.9996076,0.00004164997,0.00006159589,0.00002854891,0.00002183651,0.0002387683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4980728,0.1389001,0.01057234,0.002551246,0.001991473,0.001158532,0.0005987647,0.004582708,0.1519255,0.000772621,0.009703125,0.1791708],"study_design_scores_gemma":[0.4048916,0.56666,0.01215378,0.0000804445,0.0005538414,0.0007432124,0.00007397238,0.001181744,0.008716921,0.0001538757,0.004746432,0.00004414752],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888055,0.002443503,0.0007786002,0.0004247327,0.0001219396,0.002504007,0.001300191,0.0001839985,0.003437521],"genre_scores_gemma":[0.9851846,0.002526069,0.002441928,0.0008404557,0.0001291983,0.001909405,0.00302823,0.00004095579,0.003899262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005264317,"threshold_uncertainty_score":0.01761091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201470129370196,"score_gpt":0.2567090049202371,"score_spread":0.2446943036265351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}