{"id":"W2088600448","doi":"10.1038/nchembio.148","title":"Emerging methods for the production of homogeneous human glycoproteins","year":2008,"lang":"en","type":"review","venue":"Nature Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glycoprotein; Glycan; Glycosylation; Homogeneous; Function (biology); Computational biology; Human proteins; Biochemistry; Biology; Cell biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004170394,0.0003629119,0.0008547473,0.0001070962,0.0001668398,0.00000788843,0.0006725485,0.00194883,0.00002575225],"category_scores_gemma":[0.001828322,0.0002296878,0.0006824505,0.0002679621,0.0003600505,0.000001580997,0.000242246,0.0008656891,0.000003630891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003503125,"about_ca_system_score_gemma":0.0001979378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007534493,"about_ca_topic_score_gemma":0.000003235813,"domain_scores_codex":[0.9979904,0.0002677616,0.0005392027,0.0007136525,0.0001104995,0.0003785073],"domain_scores_gemma":[0.9983684,0.0001970107,0.0003361849,0.0007485094,0.0002804616,0.00006943275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003281885,0.00004075925,6.028479e-7,0.001073765,0.0002065701,4.91794e-7,0.000004956755,3.196407e-7,0.2127115,0.0001800399,0.001833662,0.7839145],"study_design_scores_gemma":[0.0001216322,0.0001348161,1.93686e-7,0.0002050702,0.00008821606,0.0001011837,0.000002319991,0.000001956402,0.1448369,0.00008366041,0.8542206,0.0002034822],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001118441,0.9959877,0.001376863,0.0001130613,0.0004246666,0.001771074,0.00006051076,0.00001541958,0.0001388757],"genre_scores_gemma":[0.0004211052,0.9899988,0.006144259,0.00004498947,0.00107314,0.0005788353,0.001101025,0.00005583306,0.0005820237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8523869,"threshold_uncertainty_score":0.9993469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03728885005129297,"score_gpt":0.4417279069973327,"score_spread":0.4044390569460398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}