{"id":"W2088620741","doi":"10.1371/journal.pone.0016598","title":"The Herpesvirus Associated Ubiquitin Specific Protease, USP7, Is a Negative Regulator of PML Proteins and PML Nuclear Bodies","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Promyelocytic leukemia protein; Biology; Gene silencing; SUMO protein; Nuclear protein; Ubiquitin; Suppressor; Gene isoform; Nuclear localization sequence; Cell biology; RNF4; Molecular biology; Transcription factor; Nucleus; Zinc finger; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421671,0.0004513528,0.0002895129,0.000370924,0.0002316106,0.0005306795,0.0002424038,0.0002664918,0.0008144617],"category_scores_gemma":[0.0001437437,0.0001548602,0.0002506098,0.0002041175,0.0003079811,0.0001762842,0.0004009184,0.000291344,0.000332656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003535857,"about_ca_system_score_gemma":0.0002396706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002950122,"about_ca_topic_score_gemma":0.0002528095,"domain_scores_codex":[0.9998391,0.00002008207,0.00001089975,0.00003566919,0.00007216481,0.00002224047],"domain_scores_gemma":[0.9999015,0.00001304666,0.0000368781,0.00000926095,0.00001817484,0.00002116822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329026,0.00002434886,0.001685983,0.0001564543,0.00002963625,0.0005786328,0.00002778206,0.0002398432,0.9775867,0.002253377,0.0003708335,0.01691354],"study_design_scores_gemma":[0.00002483813,0.0001802634,0.0127981,0.0000232896,0.00005109091,0.002379647,0.00006628347,0.002447393,0.9473552,0.0007972559,0.03386449,0.00001226541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.918831,0.04509979,0.02271321,0.0004428182,0.0001888558,0.00009281928,0.001256687,0.0005608944,0.01081397],"genre_scores_gemma":[0.9787981,0.007726513,0.004443151,0.00008998356,0.00003976932,0.00004008437,0.001200847,0.00003087907,0.007630665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008144617,"threshold_uncertainty_score":0.002724648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04968448488507497,"score_gpt":0.2262707981968275,"score_spread":0.1765863133117525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}