{"id":"W2088621186","doi":"10.1074/jbc.m111.290676","title":"Classically Activated Macrophages Use Stable Microtubules for Matrix Metalloproteinase-9 (MMP-9) Secretion","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; The Scarborough Hospital; University of Ottawa","funders":"University of Toronto Scarborough; University of Toronto; Canadian Institutes of Health Research; Hospital for Sick Children; University of Ottawa","keywords":"Cell biology; Secretion; Matrix metalloproteinase; Innate immune system; Extracellular matrix; Biology; Golgi apparatus; Microtubule; Chemistry; Immune system; Endoplasmic reticulum; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410429,0.0002936672,0.0001622374,0.0001645486,0.0001987729,0.0002516583,0.0001106728,0.0002407691,0.0005996293],"category_scores_gemma":[0.00008929959,0.0001058355,0.0001938836,0.0001102138,0.0001905813,0.0002287532,0.0001875718,0.0003042131,0.000386743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579636,"about_ca_system_score_gemma":0.0001827358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003845363,"about_ca_topic_score_gemma":0.0007685862,"domain_scores_codex":[0.9999005,0.00001350905,0.000008536202,0.00002718792,0.00002551216,0.00002477189],"domain_scores_gemma":[0.9999239,0.000008982422,0.00002357738,0.00001279114,0.00001926035,0.00001141333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002554102,0.000003985871,0.0001348026,0.00001813485,0.000001592567,0.00002142511,0.000008431405,0.00001102347,0.9991145,0.00009728585,0.00001506398,0.0005483034],"study_design_scores_gemma":[0.000008919058,0.0001032713,0.002275414,0.000004813215,0.000006255748,0.0001335208,0.00002036667,0.0002658422,0.9947507,0.00008819071,0.002339253,0.000003464657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832166,0.002480782,0.01188989,0.0001590619,0.00004812624,0.0000540211,0.000437173,0.00009189247,0.001622449],"genre_scores_gemma":[0.9880245,0.001144659,0.007770973,0.00004541331,0.00001413164,0.00004226233,0.0003130856,0.00001476307,0.002630163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005996293,"threshold_uncertainty_score":0.002005935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548282111708424,"score_gpt":0.268895387201511,"score_spread":0.2434125660844268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}