{"id":"W2088627390","doi":"10.1074/jbc.m504748200","title":"Modification of the Structure and Function of Fibrillin-1 by Homocysteine Suggests a Potential Pathogenetic Mechanism in Homocystinuria","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Homocystinuria; Cystathionine beta synthase; Homocysteine; Biochemistry; Fibrillin; Cysteine; Chemistry; Methionine; Biology; Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646327,0.0003233015,0.0001344905,0.0001855446,0.0002167905,0.000210561,0.0001613415,0.0005536447,0.0004342247],"category_scores_gemma":[0.0001958139,0.0001293783,0.0002322792,0.00009574877,0.0003654163,0.0002003429,0.0001439758,0.0003319995,0.0001172807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757504,"about_ca_system_score_gemma":0.00008670478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673752,"about_ca_topic_score_gemma":0.0001958912,"domain_scores_codex":[0.9999205,0.00002044627,0.000005697577,0.00001920112,0.00001824689,0.00001591034],"domain_scores_gemma":[0.999911,0.00002422582,0.00002881009,0.00001212974,0.000008545339,0.00001527394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001508899,0.0000203525,0.001550536,0.00002893234,0.000008147529,0.0005300778,0.00003577376,0.00006458914,0.9961874,0.0001025932,0.00001280457,0.001307784],"study_design_scores_gemma":[0.00001359606,0.0007377263,0.05632296,0.00001112703,0.00004910337,0.005460802,0.00007150892,0.0008092686,0.934793,0.0004116432,0.001309097,0.0000101476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965801,0.002063421,0.0008972919,0.00005534728,0.000008292086,0.000007429633,0.00002775363,0.00001398375,0.0003463888],"genre_scores_gemma":[0.9985575,0.0004870018,0.0006021187,0.00002194535,0.000005710904,0.000004682428,0.00004825274,0.000002265449,0.0002704753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005536447,"threshold_uncertainty_score":0.001452625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495698573618805,"score_gpt":0.2575814393517498,"score_spread":0.2426244536155617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}