{"id":"W2088627390","doi":"10.1074/jbc.m504748200","title":"Modification of the Structure and Function of Fibrillin-1 by Homocysteine Suggests a Potential Pathogenetic Mechanism in Homocystinuria","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Homocystinuria; Cystathionine beta synthase; Homocysteine; Biochemistry; Fibrillin; Cysteine; Chemistry; Methionine; Biology; Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001898213,0.00007500511,0.0002414104,0.00002651208,0.0000150998,0.000003674515,0.0000850506,0.0001772951,0.00007435116],"category_scores_gemma":[0.0001170101,0.00004054228,0.00007764641,0.0001156626,0.00008981293,0.0000223661,0.00003211928,0.0002330241,1.856924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002866571,"about_ca_system_score_gemma":0.00004405075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002955454,"about_ca_topic_score_gemma":4.675457e-7,"domain_scores_codex":[0.9991735,0.00003787392,0.0003850939,0.00009405205,0.0002093841,0.0001001188],"domain_scores_gemma":[0.9994135,0.00002850186,0.0002514269,0.0001106573,0.0001388483,0.000057004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003281531,0.00008818739,0.002857912,0.00007705137,0.00002191118,0.000005676622,0.00001856937,0.00002164677,0.9922812,0.000003457648,0.00004102645,0.004255183],"study_design_scores_gemma":[0.00106975,0.0004170853,0.05743491,0.00009185699,0.00003509489,0.00027449,0.00004450772,0.0002438502,0.9400521,0.0002101366,0.00008500912,0.0000412044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980755,0.001388846,0.00006857167,0.0003087118,0.00002262006,0.00007895759,0.00002245556,0.000001715581,0.0000326428],"genre_scores_gemma":[0.9993252,0.0002220534,0.0002209306,0.00001487293,0.0001250334,4.44778e-7,0.000007413855,0.00000374765,0.00008028717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.054577,"threshold_uncertainty_score":0.1653266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495698573618805,"score_gpt":0.2575814393517498,"score_spread":0.2426244536155617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}