{"id":"W2088640632","doi":"10.3109/1061186x.2013.824455","title":"Physicochemical, pharmaceutical and biological approaches toward designing optimized and efficient hydrophobically modified chitosan-based polymeric micelles as a nanocarrier system for targeted delivery of anticancer drugs","year":2013,"lang":"en","type":"review","venue":"Journal of drug targeting","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chitosan; Nanocarriers; Micelle; Drug delivery; Amphiphile; Nanotechnology; Chemistry; Anticancer drug; Combinatorial chemistry; Materials science; Drug; Copolymer; Organic chemistry; Pharmacology; Polymer; Medicine; Aqueous solution","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001860126,0.0006976666,0.002964992,0.0002933204,0.0001990468,0.0001670581,0.0005275182,0.0003128025,0.00002138644],"category_scores_gemma":[0.0004215483,0.0004911021,0.0006666268,0.0003385353,0.0005684181,0.0001482677,0.0002054175,0.0005181255,0.000004060135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359682,"about_ca_system_score_gemma":0.0006459698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001947257,"about_ca_topic_score_gemma":1.710693e-8,"domain_scores_codex":[0.9949228,0.0008383651,0.002144097,0.0007095132,0.0006620114,0.000723238],"domain_scores_gemma":[0.9944192,0.002313171,0.002338185,0.0002395716,0.0002461497,0.0004437613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007186257,0.0003126753,0.00000398904,0.01209769,0.0002387677,0.00002403974,0.0004685712,0.001871304,0.9660842,0.0000235904,0.00006514999,0.01809134],"study_design_scores_gemma":[0.00361867,0.0003202068,4.149462e-7,0.009388117,0.001837144,0.0001046727,0.001167098,0.03431992,0.9474948,0.00000949175,0.0008505944,0.0008888814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4374329,0.5603659,0.001039243,0.00003375195,0.0002241984,0.0008224486,0.00004241007,0.00003079922,0.000008336132],"genre_scores_gemma":[0.7369182,0.2246062,0.03786146,0.00004511381,0.0003413268,0.0001152416,0.00001612221,0.00009383472,0.000002466226],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3357596,"threshold_uncertainty_score":0.9997541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05458941723350067,"score_gpt":0.2908399017491429,"score_spread":0.2362504845156422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}