{"id":"W2088652149","doi":"10.1016/j.ijpharm.2014.10.040","title":"The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles","year":2014,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Program for New Century Excellent Talents in University; Ministry of Education, India; Fundamental Research Funds for the Central Universities; Priority Academic Program Development of Jiangsu Higher Education Institutions; Ministry of Earth Sciences; National Natural Science Foundation of China","keywords":"Paclitaxel; Liposome; Chemistry; Conjugate; Drug delivery; Biodistribution; PEGylation; Pharmacokinetics; Conjugated system; Nanotechnology; Pharmacology; Polyethylene glycol; Combinatorial chemistry; Materials science; In vitro; Organic chemistry; Biochemistry; Polymer; Chemotherapy; Medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002366249,0.000170174,0.0002789948,0.00006473478,0.0001040522,0.0001377065,0.0005711801,0.00003982033,0.00008635355],"category_scores_gemma":[0.001100653,0.0001248823,0.0001097007,0.00008910876,0.0004037472,0.0004853269,0.0001601441,0.0002195868,0.00001599115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009232868,"about_ca_system_score_gemma":0.00007626935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002413872,"about_ca_topic_score_gemma":0.000006233373,"domain_scores_codex":[0.997397,0.0004042327,0.0009220666,0.0001997927,0.0007905386,0.0002863884],"domain_scores_gemma":[0.9968109,0.00108774,0.0008343635,0.0001912018,0.0009030852,0.0001726927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002648717,0.0001739421,0.002818752,0.00002318342,0.00006407458,0.000008948787,0.0002605224,0.0002964836,0.9837458,0.0001933874,0.0002004619,0.01194956],"study_design_scores_gemma":[0.00106365,0.0001253407,0.001035734,0.00004834929,0.00006467852,0.00004399129,0.00009520778,0.007613526,0.9872413,0.0008423512,0.001696237,0.0001295952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994671,0.002208257,0.001084462,0.0008169223,0.0009726712,0.0001187511,0.00005495713,0.00001782734,0.00005518922],"genre_scores_gemma":[0.9983276,0.0004308986,0.0007752521,0.0002148562,0.0002022107,0.000002844592,0.000002064769,0.00001473192,0.00002955937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01181997,"threshold_uncertainty_score":0.5092553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654125311511485,"score_gpt":0.292378251535891,"score_spread":0.2758369984207762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}