{"id":"W2088654699","doi":"10.1074/jbc.m601828200","title":"Identification of a Tyrosine-based Motif (YGSI) in the Amino Terminus of Nramp1 (Slc11a1) That Is Important for Lysosomal Targeting","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Endosome; Phagolysosome; Tyrosine; Cell biology; Transport protein; Cytoplasm; Subcellular localization; Endocytosis; Lysosome; Biochemistry; Internalization; N-terminus; C-terminus; Biology; Amino acid; Proximity ligation assay; Solute carrier family; Chemistry; Peptide sequence; Intracellular; Transporter; Cell; Gene; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920743,0.0003232713,0.0004647906,0.0001538039,0.0002149365,0.0002742854,0.0003060102,0.0005891554,0.001123242],"category_scores_gemma":[0.0002917876,0.0001277025,0.000415101,0.0001302953,0.0002713765,0.0001971104,0.0002789081,0.0006791448,0.0007823749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004628479,"about_ca_system_score_gemma":0.0003173448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009737367,"about_ca_topic_score_gemma":0.0009666484,"domain_scores_codex":[0.9999065,0.00001943245,0.00001195134,0.00002149758,0.00002172226,0.00001885341],"domain_scores_gemma":[0.9997721,0.00003427329,0.00007665312,0.0000138121,0.00002977241,0.00007331262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003376222,0.00002889443,0.0007946614,0.00005672409,0.00001309614,0.0006381065,0.00002982996,0.0003486514,0.9952827,0.0002243552,0.0001244722,0.002120942],"study_design_scores_gemma":[0.0001124605,0.0005628596,0.0196703,0.00003666772,0.00005869747,0.004240526,0.0001207398,0.007755474,0.961418,0.0002056685,0.005784825,0.00003377972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914051,0.0008198658,0.006036929,0.0002808304,0.00006388575,0.00005571672,0.0004554927,0.00006529717,0.0008167778],"genre_scores_gemma":[0.9874732,0.0004086371,0.00912696,0.000159497,0.00002823414,0.00003824406,0.001356257,0.00002551099,0.001383381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123242,"threshold_uncertainty_score":0.003757656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118812441263689,"score_gpt":0.2694292745882143,"score_spread":0.2482411501755774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}