{"id":"W2088655043","doi":"10.1159/000341630","title":"Bacterial Stimulation of the TLR-MyD88 Pathway Modulates the Homeostatic Expression of Ileal Paneth Cell α-Defensins","year":2012,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Michael Smith Health Research BC; Genome British Columbia; Child and Family Research Institute; Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Paneth cell; Biology; Microbiology; Gene expression; Cell biology; Gene; Biochemistry; Small intestine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328818,0.0002286989,0.0001980573,0.0001258962,0.00008749315,0.0002158331,0.00008843623,0.0002002342,0.0007581884],"category_scores_gemma":[0.0001324379,0.0001315274,0.0001483282,0.00005779466,0.0002014453,0.0002011322,0.0001807833,0.0005915133,0.0002062802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435376,"about_ca_system_score_gemma":0.00009194557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007901746,"about_ca_topic_score_gemma":0.0001599696,"domain_scores_codex":[0.999859,0.00003271463,0.00001153736,0.00002530055,0.00002031193,0.00005115865],"domain_scores_gemma":[0.9999156,0.0000116402,0.0000210134,0.00001012653,0.000008075764,0.00003354104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003086229,0.00002360345,0.0002774809,0.00001803395,0.000001412186,0.00002179129,0.000007547583,0.00001329614,0.9984314,0.00001857751,0.00001063548,0.0008675369],"study_design_scores_gemma":[0.00006129619,0.001198227,0.03406169,0.00001405864,0.00001479557,0.0002615904,0.00009428459,0.0008226762,0.9623172,0.00006905723,0.001080053,0.000005013474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981095,0.0007947928,0.0004889847,0.00005689307,0.00001119123,0.000008422732,0.00007740283,0.00001634825,0.0004365291],"genre_scores_gemma":[0.9979347,0.0004130196,0.0005326679,0.00003669502,0.000006990761,0.00002115812,0.000121028,0.000005947978,0.0009277997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007581884,"threshold_uncertainty_score":0.002536416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449204401356369,"score_gpt":0.2210331881405517,"score_spread":0.206541144126988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}