{"id":"W2088658362","doi":"10.1046/j.1365-2516.2001.00492.x","title":"Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: concurrent tumourigenesis","year":2001,"lang":"en","type":"article","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Canadian Blood Services; McMaster University","keywords":"Factor IX; Medicine; Haemophilia; C2C12; Genetic enhancement; Haemophilia A; Antibody; Transgene; Cancer research; Immunology; Haemophilia B; Genetically modified mouse; Partial thromboplastin time; Internal medicine; Myocyte; Biology; Coagulation; Surgery; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096093,0.0004100939,0.0003541001,0.0003150709,0.0001468249,0.0003455211,0.0002693556,0.0007028064,0.0004981616],"category_scores_gemma":[0.0001106479,0.0001512,0.0002563452,0.0001762904,0.0002987182,0.0002456607,0.0002176027,0.0006533372,0.000235237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172588,"about_ca_system_score_gemma":0.0002261049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001210186,"about_ca_topic_score_gemma":0.001502875,"domain_scores_codex":[0.9998022,0.00002356154,0.00001538977,0.00005290629,0.00007371845,0.00003227977],"domain_scores_gemma":[0.9998664,0.00001469779,0.00005477681,0.0000175983,0.00001182711,0.00003469988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006503004,0.00001524397,0.00002833652,0.00001497312,0.000002444157,0.00001962366,0.00001142731,0.00003981049,0.9990602,0.00004952119,0.00001223238,0.0006810405],"study_design_scores_gemma":[0.00002536423,0.0005463689,0.001175504,0.000005204281,0.00001827022,0.0002353401,0.00001309109,0.0006439881,0.9951168,0.00002008009,0.002194251,0.000005678128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874588,0.002838691,0.007303321,0.00008628864,0.00004184075,0.0001108787,0.0003116725,0.0001726923,0.001675879],"genre_scores_gemma":[0.9844851,0.002459589,0.007991801,0.0000414519,0.0000203847,0.0001301999,0.0003376941,0.00005148167,0.004482182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210186,"threshold_uncertainty_score":0.002406359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590678134757349,"score_gpt":0.2775378528316898,"score_spread":0.2616310714841163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}