{"id":"W2088658362","doi":"10.1046/j.1365-2516.2001.00492.x","title":"Sustained and therapeutic delivery of factor IX in nude haemophilia B mice by encapsulated C2C12 myoblasts: concurrent tumourigenesis","year":2001,"lang":"en","type":"article","venue":"Haemophilia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Canadian Blood Services; McMaster University","keywords":"Factor IX; Medicine; Haemophilia; C2C12; Genetic enhancement; Haemophilia A; Antibody; Transgene; Cancer research; Immunology; Haemophilia B; Genetically modified mouse; Partial thromboplastin time; Internal medicine; Myocyte; Biology; Coagulation; Surgery; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000294122,0.000325077,0.0003741928,0.0001634036,0.00007376391,0.00002546598,0.0003585474,0.0002384735,0.0001362411],"category_scores_gemma":[0.00005788023,0.0003190412,0.0001084241,0.0003295221,0.000256938,0.000009060344,0.0001937931,0.0001884863,0.0000114035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006681311,"about_ca_system_score_gemma":0.0001769364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001312765,"about_ca_topic_score_gemma":0.0003009453,"domain_scores_codex":[0.9978044,0.0002184649,0.0004513249,0.000595059,0.0003085114,0.000622225],"domain_scores_gemma":[0.9990193,0.00004340661,0.0001298785,0.0004263963,0.0001924022,0.0001886696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001371927,0.0002113405,0.006003831,0.00005248913,0.00009827112,0.00002722534,0.0001575758,0.00003335315,0.974796,0.00001162497,0.0004814529,0.0167549],"study_design_scores_gemma":[0.002710052,0.002087941,0.009628909,0.00005043456,0.00002905794,0.00003451048,0.0002460761,0.000470638,0.9804618,0.0001969431,0.00357659,0.0005070088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887696,0.01005463,0.00004555749,0.0003066089,0.00009066322,0.0004770731,0.0001190688,0.0000195718,0.0001172496],"genre_scores_gemma":[0.9960675,0.002840567,0.00002419781,0.0002236839,0.00008467878,0.00003026819,0.0001222775,0.00005271616,0.0005540762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01624789,"threshold_uncertainty_score":0.9999261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590678134757349,"score_gpt":0.2775378528316898,"score_spread":0.2616310714841163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}