{"id":"W2088678946","doi":"10.1371/journal.pone.0011703","title":"Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Canadian Institutes of Health Research; Arthritis Foundation; University of Michigan; National Institute of Allergy and Infectious Diseases; American College of Rheumatology Research and Education Foundation","keywords":"Calreticulin; Epitope; Rheumatoid arthritis; Identification (biology); Computational biology; Binding site; Medicine; Bioinformatics; Biology; Immunology; Genetics; Antibody; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118209,0.0002597787,0.0002451134,0.000151048,0.0001359356,0.0001443554,0.0002308954,0.0002623493,0.001200279],"category_scores_gemma":[0.0002039173,0.00006941578,0.0002826688,0.0001035921,0.0001343041,0.00009478293,0.0001916523,0.0003833415,0.0006316759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003320739,"about_ca_system_score_gemma":0.0001553297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005189501,"about_ca_topic_score_gemma":0.000546891,"domain_scores_codex":[0.9999301,0.00001296909,0.000003953378,0.00001656504,0.00002175092,0.00001466122],"domain_scores_gemma":[0.9998585,0.00003679136,0.00003588847,0.00001494289,0.00002622568,0.0000276013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001838283,0.00003285072,0.0009029823,0.00003820342,0.000007351339,0.0001126841,0.00001781652,0.0001668095,0.9964398,0.00008650102,0.00003483889,0.001976338],"study_design_scores_gemma":[0.00003999498,0.000308168,0.01847958,0.00002091316,0.00003762064,0.001005078,0.00005892673,0.005978638,0.971045,0.0001452141,0.002869066,0.00001172107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935939,0.0005854093,0.004881006,0.00006616173,0.00001133081,0.00002469964,0.0001453409,0.00002641236,0.0006656733],"genre_scores_gemma":[0.9895773,0.0002515989,0.00875474,0.0000676409,0.000005705951,0.00001514882,0.0005855713,0.000009836179,0.0007326133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200279,"threshold_uncertainty_score":0.004015386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266311926193179,"score_gpt":0.2469272121892946,"score_spread":0.2242640929273628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}