{"id":"W2088678949","doi":"10.1021/bi0119161","title":"Pentavalent Ions Dependency Is a Conserved Property of Adenosine Kinase from Diverse Sources:  Identification of a Novel Motif Implicated in Phosphate and Magnesium Ion Binding and Substrate Inhibition","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"University of British Columbia; McMaster University","keywords":"Adenosine; Biochemistry; Mutant; Adenosine kinase; Chemistry; Kinase; Adenosine triphosphate; Binding site; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139051,0.0001479593,0.0001669195,0.00004403563,0.00004012421,0.00001850927,0.0001012725,0.0002014238,0.00004307202],"category_scores_gemma":[0.00006771225,0.0001291864,0.00005052717,0.000129225,0.000210621,0.000007326624,0.0001512489,0.00009578725,0.000001367601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001408901,"about_ca_system_score_gemma":0.0000241477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112531,"about_ca_topic_score_gemma":0.00001439003,"domain_scores_codex":[0.9988429,0.00002463329,0.0003691445,0.000429999,0.0001565005,0.0001768495],"domain_scores_gemma":[0.9993681,0.000009317541,0.0001732516,0.0002504388,0.0001046576,0.00009427392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008497832,0.0002806806,0.009121902,0.000224388,0.00002083803,0.000002719444,0.00006618269,5.713268e-7,0.9896479,0.000002080765,0.00007828444,0.0004694429],"study_design_scores_gemma":[0.001297908,0.00005835136,0.00769812,0.00007200111,0.00002494531,0.000009402947,0.0001517653,0.00022872,0.9902807,0.00001024346,0.00001980256,0.0001480061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968835,0.00232617,0.00005822328,0.0001787425,0.00001283404,0.0002200059,0.0002772468,0.000005725809,0.00003758764],"genre_scores_gemma":[0.9986894,0.0005526078,0.0001189737,0.00002415206,0.00002046715,0.00002039264,0.0003101749,0.000012845,0.0002510155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805908,"threshold_uncertainty_score":0.5268068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02837888141432132,"score_gpt":0.2470407418568887,"score_spread":0.2186618604425674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}