{"id":"W2088738439","doi":"10.1186/1742-4690-7-44","title":"Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes","year":2010,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"McGill University; Canadian Institutes of Health Research; Merck Canada; Canadian Foundation for AIDS Research; Health Research","keywords":"Raltegravir; Integrase inhibitor; Downregulation and upregulation; Virology; Biology; DNA; Molecular biology; Cell culture; Integrase; Complementary DNA; Flow cytometry; CXCR4; Virus; Cell biology; Chemokine; Gene; Viral load; Human immunodeficiency virus (HIV); Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357145,0.0002725805,0.0001852092,0.0001851553,0.00009324306,0.0004051674,0.0002063473,0.0003381631,0.001467719],"category_scores_gemma":[0.000139408,0.0000968583,0.0002139834,0.00009635219,0.000214747,0.0001341026,0.0001273619,0.0006424268,0.0004117966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003378852,"about_ca_system_score_gemma":0.0001821082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005091158,"about_ca_topic_score_gemma":0.0007302953,"domain_scores_codex":[0.9998276,0.00002338159,0.00001473454,0.00002993364,0.0000573147,0.00004697964],"domain_scores_gemma":[0.9998846,0.00003599848,0.00002567458,0.00001792167,0.00001133449,0.00002453051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003941761,0.00002616986,0.00008996557,0.0000240139,0.00000227116,0.00001506525,0.000008149619,0.00003401736,0.9990577,0.00003175363,0.00001815824,0.0006534014],"study_design_scores_gemma":[0.00001254195,0.0001907251,0.001650694,0.000005952753,0.000008658191,0.0001178992,0.00001168302,0.0004357122,0.9960868,0.00001330562,0.00146372,0.000002225984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949049,0.001096175,0.002429701,0.00006811085,0.00003180568,0.00003176221,0.0003783337,0.00006133727,0.0009979527],"genre_scores_gemma":[0.9919345,0.0005748319,0.003459702,0.00005864777,0.00001510643,0.000041087,0.0011213,0.00002640957,0.002768276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467719,"threshold_uncertainty_score":0.004909933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005761279092589448,"score_gpt":0.2152520159157945,"score_spread":0.209490736823205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}