{"id":"W2088751122","doi":"10.1073/pnas.1215349109","title":"Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Medical Research Council; Muscular Dystrophy Association","keywords":"Frataxin; Mitochondrion; Ataxia; Biology; Oxidative stress; Biochemistry; Cell biology; Chemistry; Molecular biology; Aconitase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005469499,0.00009016726,0.0001597374,0.0002145528,0.00007288263,0.00001125473,0.0007925673,0.00005417371,0.000003324654],"category_scores_gemma":[0.001784426,0.00007032351,0.00006427639,0.0006524875,0.000734445,0.0005414249,0.000139575,0.0000943553,6.430644e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001929459,"about_ca_system_score_gemma":0.00004652347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000479828,"about_ca_topic_score_gemma":1.782269e-7,"domain_scores_codex":[0.997773,0.00002181766,0.0005531704,0.0002493125,0.001237056,0.0001656489],"domain_scores_gemma":[0.9988998,0.0001208709,0.0007040271,0.00001615919,0.0002196665,0.00003954748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002308801,0.0001582105,0.009401908,0.00006478755,0.000001068529,6.924618e-10,0.0002533555,0.002016901,0.9724456,0.01556314,0.00004182149,0.00003013108],"study_design_scores_gemma":[0.0001658834,0.00002664545,0.02616094,0.00003051521,0.000007133638,8.842381e-7,0.00005780023,0.006835635,0.9627613,0.003895229,8.969994e-7,0.00005712916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989042,0.00004253266,0.00001028422,0.0002479423,0.00002754807,0.0002461524,0.00007041957,0.000004378005,0.0004465267],"genre_scores_gemma":[0.9989753,0.00001592208,0.0007908093,0.00006538259,0.00003623345,0.00001546343,9.426869e-8,0.000004689547,0.0000961469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01675903,"threshold_uncertainty_score":0.286771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06613243460653245,"score_gpt":0.3154738766079345,"score_spread":0.2493414420014021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}