{"id":"W2088756547","doi":"10.1126/science.290.5498.1959","title":"Glucose-Dependent Insulin Release from Genetically Engineered K Cells","year":2000,"lang":"en","type":"article","venue":"Science","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":293,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Insulin; Transgene; Diabetes mellitus; Internal medicine; Endocrinology; Beta cell; Cell culture; Human insulin; Biology; Gene; Genetically modified mouse; Medicine; Biochemistry; Islet; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356049,0.0003229891,0.0002296547,0.0001054272,0.00008209121,0.0003289607,0.0002233274,0.0002096119,0.0007530844],"category_scores_gemma":[0.0001310355,0.000136917,0.0002652477,0.0001055344,0.0001412965,0.0001863538,0.0001795383,0.0005369408,0.0004765057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845771,"about_ca_system_score_gemma":0.00014092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001813705,"about_ca_topic_score_gemma":0.0002543387,"domain_scores_codex":[0.9999069,0.00001190439,0.00001515023,0.00002369498,0.00001929212,0.00002301745],"domain_scores_gemma":[0.9999095,0.00001729791,0.00002759331,0.00001838887,0.00001051922,0.00001673207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429973,0.00002332011,0.0000884742,0.00002568367,0.000003269267,0.00005450613,0.00001089904,0.00004788363,0.9984262,0.0001023444,0.00004115653,0.001033417],"study_design_scores_gemma":[0.00005242772,0.0002373355,0.0008869267,0.000004881484,0.0000147862,0.000203867,0.000010168,0.0004170331,0.9955519,0.00003373023,0.002582442,0.000004438928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899831,0.0008770733,0.005874781,0.0001054174,0.0001027614,0.00005162058,0.0004964899,0.0001395361,0.00236916],"genre_scores_gemma":[0.9902535,0.000880545,0.004080423,0.00006520435,0.00001717382,0.00003731875,0.000645128,0.00006919428,0.003951479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007530844,"threshold_uncertainty_score":0.00251931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008668420759061948,"score_gpt":0.2257326492707589,"score_spread":0.2170642285116969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}