{"id":"W2088780747","doi":"10.1021/ol100427v","title":"Total Synthesis of “Aliskiren”: The First Renin Inhibitor in Clinical Practice for Hypertension","year":2010,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Aliskiren; Chemistry; Renin inhibitor; Renin–angiotensin system; Pharmacology; Plasma renin activity; Combinatorial chemistry; Internal medicine; Blood pressure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005891045,0.0001227558,0.0002389054,0.00003005483,0.00008934124,0.00002507371,0.0002217956,0.0001498732,0.0002906523],"category_scores_gemma":[0.005292443,0.00008624553,0.0001594421,0.0001088783,0.0001237067,0.0001184608,0.00004856947,0.0003472415,0.00002577965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000300472,"about_ca_system_score_gemma":0.00005711346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122889,"about_ca_topic_score_gemma":0.0001206688,"domain_scores_codex":[0.9988638,0.0000226907,0.0004856898,0.0002564431,0.0001830723,0.00018836],"domain_scores_gemma":[0.9956103,0.003533125,0.0002246108,0.0005318612,0.00005550715,0.0000445708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005822434,0.0002228217,0.001162848,0.0000246664,0.0000450029,0.000006597888,0.0000951535,7.431443e-7,0.978821,0.00005747681,0.01327905,0.006226469],"study_design_scores_gemma":[0.000614628,0.00001879283,0.006025502,0.00007643838,0.0001861887,0.0001416612,0.0004851714,0.0001016292,0.9392866,0.0000160609,0.05283349,0.0002138016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717183,0.00001544484,0.00002223571,0.02696275,0.0004144394,0.00009680793,0.00001391395,0.00002418514,0.0007319646],"genre_scores_gemma":[0.9978116,0.00001391111,0.0005173557,0.00104539,0.0004828762,0.00004270052,0.000004611495,0.00002969296,0.00005188593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03955445,"threshold_uncertainty_score":0.6335931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553018369936236,"score_gpt":0.25817935177282,"score_spread":0.2426491680734576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}