{"id":"W2088780747","doi":"10.1021/ol100427v","title":"Total Synthesis of “Aliskiren”: The First Renin Inhibitor in Clinical Practice for Hypertension","year":2010,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Aliskiren; Chemistry; Renin inhibitor; Renin–angiotensin system; Pharmacology; Plasma renin activity; Combinatorial chemistry; Internal medicine; Blood pressure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155418,0.0005951668,0.0002541436,0.0003576512,0.0002967635,0.0003217993,0.0004266032,0.0003115545,0.005693404],"category_scores_gemma":[0.0001654599,0.0001671833,0.0002874937,0.0001854901,0.0001981753,0.0003605247,0.0004788755,0.000475441,0.002779977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742904,"about_ca_system_score_gemma":0.0006425033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003881438,"about_ca_topic_score_gemma":0.0008831481,"domain_scores_codex":[0.9998837,0.00001758276,0.00001340305,0.00002890769,0.0000287164,0.00002782447],"domain_scores_gemma":[0.9999346,0.000005303796,0.00001515614,0.00001050814,0.00001143667,0.00002302524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003039703,0.0001642481,0.0003665594,0.0005717822,0.00005267196,0.001386875,0.0002004648,0.001741199,0.8505816,0.01017173,0.003426657,0.1310323],"study_design_scores_gemma":[0.0001317712,0.002170102,0.001596605,0.00007403364,0.0001153151,0.002052381,0.00004035244,0.00113099,0.8381084,0.001597603,0.1529265,0.0000559169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5206664,0.0292264,0.2943015,0.002894134,0.001753088,0.001851244,0.005462549,0.002776565,0.1410682],"genre_scores_gemma":[0.8781448,0.01668103,0.07260633,0.0006965991,0.0002810009,0.0004415826,0.001777687,0.0002405165,0.02913056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005693404,"threshold_uncertainty_score":0.01904637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553018369936236,"score_gpt":0.25817935177282,"score_spread":0.2426491680734576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}