{"id":"W2088819616","doi":"10.1038/onc.2009.479","title":"Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Biology; Prostate cancer; Heat shock protein; Androgen; Cancer research; Prostate; EIF4E; Chemotherapy; Cancer; Ablation; Internal medicine; Endocrinology; Oncology; Gene; Biochemistry; Hormone; Genetics; Messenger RNA; Medicine; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796686,0.0003261415,0.0004711265,0.0005216126,0.0003356383,0.0004544395,0.0002992181,0.0002349207,0.003720711],"category_scores_gemma":[0.0001960721,0.0003043349,0.0005588735,0.0004067879,0.0003817023,0.0001928416,0.0003499622,0.001095196,0.000594278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005065541,"about_ca_system_score_gemma":0.0005499193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001627275,"about_ca_topic_score_gemma":0.002282347,"domain_scores_codex":[0.9997895,0.00003168843,0.0000171617,0.00002622262,0.00005637481,0.00007903834],"domain_scores_gemma":[0.9998287,0.00004607141,0.00002270615,0.00004063706,0.00001456776,0.00004723279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004123496,0.0001804409,0.0003799968,0.0000244686,0.00001977778,0.00009140088,0.00002044533,0.000273172,0.9962024,0.0002263289,0.0003370134,0.001832141],"study_design_scores_gemma":[0.00003200956,0.000453303,0.006737119,0.000004119274,0.00002325858,0.0002836663,0.00005052426,0.001424335,0.98763,0.00006460575,0.003288878,0.000008066077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939908,0.0009213269,0.00142269,0.0003210453,0.0001067579,0.00003785604,0.0006614491,0.0001657069,0.002372284],"genre_scores_gemma":[0.9915633,0.0006712615,0.0009266006,0.00006483015,0.00001448065,0.00003481975,0.00175874,0.00005192539,0.0049139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003720711,"threshold_uncertainty_score":0.012447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850167401492246,"score_gpt":0.3207297933702062,"score_spread":0.3022281193552837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}