{"id":"W2088819616","doi":"10.1038/onc.2009.479","title":"Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Biology; Prostate cancer; Heat shock protein; Androgen; Cancer research; Prostate; EIF4E; Chemotherapy; Cancer; Ablation; Internal medicine; Endocrinology; Oncology; Gene; Biochemistry; Hormone; Genetics; Messenger RNA; Medicine; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499846,0.00014884,0.0002356833,0.00007410815,0.00005582087,0.00002664634,0.00005407672,0.00007718625,0.0001954155],"category_scores_gemma":[0.00001121737,0.0001184401,0.00002877782,0.0002448818,0.00007627727,0.00009061422,0.00002296864,0.0001885595,0.0000174078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413776,"about_ca_system_score_gemma":0.0002394799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003570343,"about_ca_topic_score_gemma":0.001512903,"domain_scores_codex":[0.9989238,0.00002228245,0.0001756761,0.0003368418,0.0002261026,0.000315251],"domain_scores_gemma":[0.9995065,0.00001468376,0.00002040159,0.0002168989,0.00008926623,0.0001521939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001488172,0.0001000724,0.01716118,0.0001035352,0.00003886422,0.00005198874,0.001310244,0.000003777183,0.9719337,0.00003527119,0.001430684,0.006342558],"study_design_scores_gemma":[0.004137081,0.0002387667,0.004427917,0.0001814906,0.00001599465,0.000005316038,0.00008925703,0.00003812827,0.9126246,0.0001319417,0.07794954,0.0001599504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872103,0.001290877,0.0000150779,0.00742501,0.0001225772,0.001857718,0.00003684411,0.00002776927,0.002013794],"genre_scores_gemma":[0.9811835,0.001530216,0.001883663,0.0006884179,0.0001427174,0.000344274,0.00002902537,0.0000389402,0.01415921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07651886,"threshold_uncertainty_score":0.4829848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850167401492246,"score_gpt":0.3207297933702062,"score_spread":0.3022281193552837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}