{"id":"W2088909504","doi":"10.1074/jbc.m113.483198","title":"Deficiency of a Glycogen Synthase-associated Protein, Epm2aip1, Causes Decreased Glycogen Synthesis and Hepatic Insulin Resistance","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glycogen synthase; Insulin resistance; Glycogen; Internal medicine; Dephosphorylation; Endocrinology; Allosteric regulation; Insulin; Biology; Glycogen phosphorylase; Glycogenesis; Glycogen debranching enzyme; Glycogen branching enzyme; Chemistry; Biochemistry; Enzyme; Phosphatase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215641,0.0005101633,0.0002793702,0.0006358706,0.0001125086,0.0002313822,0.0002029099,0.0002937123,0.001442386],"category_scores_gemma":[0.0001730616,0.0001568791,0.0002062684,0.0003339696,0.0002697113,0.0001547054,0.000239693,0.000478461,0.0002395333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000217299,"about_ca_system_score_gemma":0.00008477134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002122386,"about_ca_topic_score_gemma":0.000251957,"domain_scores_codex":[0.999872,0.000026497,0.00002150032,0.00003314896,0.00002761779,0.00001926492],"domain_scores_gemma":[0.9998438,0.00002069671,0.0000613079,0.00001507688,0.000008314983,0.00005080214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004064259,0.00004679354,0.001307239,0.00004118947,0.00001331443,0.0004787013,0.00001019038,0.00008036231,0.995626,0.00009181726,0.00008637896,0.00181165],"study_design_scores_gemma":[0.0001618404,0.0008434054,0.06472307,0.00002695147,0.0001082709,0.007535785,0.00006491301,0.001977531,0.9214078,0.0002328294,0.002900061,0.00001756621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956589,0.0007204351,0.002233354,0.0001093767,0.00001747704,0.00001341335,0.0005459239,0.0001134683,0.0005878167],"genre_scores_gemma":[0.9959878,0.0005273399,0.001472487,0.00004928146,0.00000929138,0.00002546381,0.000690462,0.00002184983,0.001216063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442386,"threshold_uncertainty_score":0.004825234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648372042576499,"score_gpt":0.2381593587311992,"score_spread":0.2216756383054342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}