{"id":"W2088909504","doi":"10.1074/jbc.m113.483198","title":"Deficiency of a Glycogen Synthase-associated Protein, Epm2aip1, Causes Decreased Glycogen Synthesis and Hepatic Insulin Resistance","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glycogen synthase; Insulin resistance; Glycogen; Internal medicine; Dephosphorylation; Endocrinology; Allosteric regulation; Insulin; Biology; Glycogen phosphorylase; Glycogenesis; Glycogen debranching enzyme; Glycogen branching enzyme; Chemistry; Biochemistry; Enzyme; Phosphatase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073449,0.0002303479,0.0007173122,0.00004919934,0.00006607939,0.00002164343,0.0001813074,0.0002522631,0.000578514],"category_scores_gemma":[0.004731996,0.0001532058,0.0002743415,0.0002072207,0.0002439204,0.00006858888,0.00005604532,0.0002410713,0.000006451164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009064483,"about_ca_system_score_gemma":0.000202804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004740631,"about_ca_topic_score_gemma":0.00000172768,"domain_scores_codex":[0.9982508,0.00007584619,0.0007688765,0.0002451036,0.0003506298,0.0003087415],"domain_scores_gemma":[0.9977844,0.0002994567,0.000709825,0.0002196805,0.0005548262,0.0004317666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000986689,0.0008115451,0.01302173,0.00044135,0.0002079024,0.001010978,0.00003531724,5.389247e-7,0.9817936,0.000006567168,0.0003310382,0.001352672],"study_design_scores_gemma":[0.002779731,0.0008413597,0.05054644,0.001580536,0.0006885967,0.001210264,0.000466317,0.0000323781,0.9401329,0.0006345445,0.0006440843,0.000442804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922264,0.006538518,0.00001781751,0.0002841363,0.00002201729,0.000303649,0.00005543289,0.0000200536,0.0005319839],"genre_scores_gemma":[0.9985031,0.0003901416,0.0007142421,0.0001029978,0.00007845717,0.00003111533,0.00000905919,0.00001513695,0.0001557653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04166073,"threshold_uncertainty_score":0.6334323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648372042576499,"score_gpt":0.2381593587311992,"score_spread":0.2216756383054342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}