{"id":"W2088941584","doi":"10.1371/journal.ppat.1002659","title":"Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Inflammasome; Cleavage (geology); Proteolysis; Protease; Cell biology; Mutant; Biology; Caspase; Receptor; Chemistry; Biochemistry; Enzyme; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677793,0.0001498969,0.0001787214,0.00004059991,0.00008194273,0.00000942739,0.0001297179,0.000143777,0.00001542838],"category_scores_gemma":[0.0001236446,0.0001436755,0.0001325824,0.00008082664,0.00006392675,0.00001623537,0.00006647874,0.00005228975,0.000008081291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009981994,"about_ca_system_score_gemma":0.00007584722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001783981,"about_ca_topic_score_gemma":9.891343e-7,"domain_scores_codex":[0.9990852,0.00002829381,0.0001976233,0.0002031987,0.0001143562,0.0003713171],"domain_scores_gemma":[0.9993615,0.000007991889,0.0001487995,0.0002919047,0.0001296086,0.00006020447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255777,0.0001565604,0.00642222,0.0001771214,0.0000521006,1.951308e-7,0.0003260404,0.00000147685,0.9849483,0.00001475293,0.0001180629,0.007657555],"study_design_scores_gemma":[0.0004910428,0.00017689,0.004532994,0.00002700721,0.00005150685,0.000002139662,0.00008583871,0.00007739905,0.9898807,0.00004493445,0.004436719,0.0001928752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968605,0.0007114225,0.0008959444,0.00007338052,0.00006166562,0.000567694,0.00004875893,0.00001356564,0.0007670346],"genre_scores_gemma":[0.9978582,0.00003465667,0.001173306,0.00008829324,0.0002025991,0.0001587353,0.00004835004,0.00003241304,0.0004035026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00746468,"threshold_uncertainty_score":0.5858918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206081463827844,"score_gpt":0.2596356175516215,"score_spread":0.2375748029133431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}