{"id":"W2088941584","doi":"10.1371/journal.ppat.1002659","title":"Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Inflammasome; Cleavage (geology); Proteolysis; Protease; Cell biology; Mutant; Biology; Caspase; Receptor; Chemistry; Biochemistry; Enzyme; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946943,0.0003472069,0.0003722697,0.0001634656,0.0002183376,0.0004584929,0.0001638159,0.0003916628,0.00128329],"category_scores_gemma":[0.0003001699,0.0001791159,0.0003022008,0.0001550351,0.0003321825,0.0003094565,0.0002488379,0.0006920989,0.0006899498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561847,"about_ca_system_score_gemma":0.0002198877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433282,"about_ca_topic_score_gemma":0.0001997327,"domain_scores_codex":[0.9997218,0.00004225876,0.00003882181,0.00007407524,0.00007237322,0.00005064936],"domain_scores_gemma":[0.9997216,0.00004457934,0.0001012297,0.00004220526,0.00002434938,0.00006616835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004667038,0.00001269977,0.000110857,0.00001521186,0.000001813551,0.00006246778,0.000006488869,0.00002152353,0.9993831,0.00006295417,0.00001416391,0.0002620485],"study_design_scores_gemma":[0.00002362705,0.0001297816,0.01270478,0.00001123871,0.000006859622,0.00143344,0.00003475089,0.0006026988,0.9822289,0.0001391123,0.002679001,0.000005807179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908922,0.001999415,0.004776776,0.0002590754,0.00004034273,0.00002765524,0.000609113,0.0001176769,0.001277686],"genre_scores_gemma":[0.9947184,0.0004721384,0.00282378,0.00005052479,0.000008513595,0.00002477433,0.0007503881,0.00003439136,0.001117128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00128329,"threshold_uncertainty_score":0.004293025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206081463827844,"score_gpt":0.2596356175516215,"score_spread":0.2375748029133431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}