{"id":"W2088968901","doi":"10.1371/journal.ppat.1000852","title":"Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":594,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; Hamilton Health Sciences; Canadian Foundation for AIDS Research","keywords":"Tight junction; Barrier function; Occludin; Biology; Epithelium; Intestinal permeability; Cell biology; Chromosomal translocation; Immunology; Microbiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002854605,0.0002356585,0.000279919,0.0001369709,0.0002735238,0.00002988431,0.0002569976,0.0003158001,0.001390342],"category_scores_gemma":[0.000229007,0.00019882,0.0001735255,0.000144344,0.0001171065,0.00008537569,0.00005761117,0.0007431285,0.005549097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004946167,"about_ca_system_score_gemma":0.0001660465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008239086,"about_ca_topic_score_gemma":0.0005092844,"domain_scores_codex":[0.9984185,0.0002056755,0.0002653643,0.0004325698,0.00007435247,0.0006035587],"domain_scores_gemma":[0.9992207,0.0001029612,0.00003714601,0.0003853222,0.0001125396,0.0001412983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961456,0.0003596619,0.00628492,0.0000105099,0.000196292,0.00003579546,0.001431028,0.000001101625,0.9768039,0.00004693792,0.001233593,0.01340013],"study_design_scores_gemma":[0.001835302,0.0004440472,0.01432662,0.00002832195,0.00007776728,0.00005527894,0.0001682981,0.000003481591,0.9644154,0.00002889412,0.0183162,0.0003004393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952973,0.0001798216,0.000217612,0.0008245901,0.000687995,0.0005219942,0.001517373,0.0001385721,0.0006147737],"genre_scores_gemma":[0.9968362,0.000018788,0.001052609,0.0001299417,0.0001525029,0.0001091255,0.0005799159,0.00003070353,0.001090212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0170826,"threshold_uncertainty_score":0.9995225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346141570723703,"score_gpt":0.2466985950793983,"score_spread":0.2332371793721612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}