{"id":"W2088974721","doi":"10.1016/j.biopsych.2010.07.009","title":"Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors","year":2010,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; U.S. Department of Health and Human Services; National Institutes of Health; School of Medicine, Johns Hopkins University; Ministero dell’Istruzione, dell’Università e della Ricerca; School of Medicine, University of Maryland","keywords":"Palmitoylethanolamide; Nicotine; Ventral tegmental area; Endocannabinoid system; Nucleus accumbens; Neurochemical; Dopamine; Fatty acid amide hydrolase; Chemistry; Pharmacology; Endocrinology; Internal medicine; Anandamide; Antagonist; Receptor; Cannabinoid receptor; Medicine; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694418,0.0002217818,0.0003109137,0.00008343366,0.00006955765,0.00001425944,0.0002904137,0.0002141732,0.000279379],"category_scores_gemma":[0.000261591,0.0001660781,0.00006635538,0.000373903,0.0003965464,0.000147251,0.00005886496,0.0003917907,0.000009387287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001171221,"about_ca_system_score_gemma":0.00004866645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001043237,"about_ca_topic_score_gemma":0.00000107249,"domain_scores_codex":[0.9982377,0.000150793,0.0005411291,0.0005430433,0.0002575733,0.0002697444],"domain_scores_gemma":[0.9990948,0.00009163019,0.0003119769,0.000306093,0.00007160462,0.0001238868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002227547,0.000362642,0.1001057,0.00002707702,0.000003964019,2.428493e-7,0.00003366624,4.314326e-7,0.8977056,0.0002651808,0.0004650742,0.0008077596],"study_design_scores_gemma":[0.0005417734,0.0008217423,0.01439798,0.00002784254,0.000007755838,0.000005666122,0.00002178223,0.000002168,0.9809968,0.0001965822,0.002801067,0.0001788169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974239,0.00002782504,0.000009295765,0.0008406685,0.0009891378,0.0005066562,0.00003386103,0.00007668278,0.00009193356],"genre_scores_gemma":[0.9985369,0.00007715486,0.0008368756,0.0003926382,0.00006229537,0.00002253219,0.000008551781,0.00001869628,0.00004434743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08570768,"threshold_uncertainty_score":0.6772468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0313733246581021,"score_gpt":0.2901285526445552,"score_spread":0.2587552279864531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}