{"id":"W2088983187","doi":"10.1016/j.bmc.2008.06.023","title":"The discovery of small molecule chemical probes of Bcl-XL and Mcl-1","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Steacie Institute for Molecular Sciences; Biotechnology Research Institute; McGill University; Ontario Institute for Cancer Research","funders":"Broad Institute; Abbott Laboratories","keywords":"Chemistry; Small molecule; In silico; Molecule; Chemical library; Scaffold; Combinatorial chemistry; Stereochemistry; Bcl-xL; Drug discovery; Biophysics; Biochemistry; Organic chemistry; Database","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000372039,0.0003749777,0.0002186857,0.0003657338,0.0002304955,0.0004409077,0.0004514266,0.0004708814,0.002487006],"category_scores_gemma":[0.0004103833,0.0002345901,0.0001907682,0.0001609276,0.0003607274,0.0005092783,0.0003646629,0.001130974,0.0003888922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005672451,"about_ca_system_score_gemma":0.0002824576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918772,"about_ca_topic_score_gemma":0.0006896973,"domain_scores_codex":[0.999921,0.00001636196,0.000003088028,0.00001413872,0.00002274496,0.00002260986],"domain_scores_gemma":[0.9998926,0.00003817888,0.00002232436,0.000008054311,0.00001520242,0.00002359754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005384302,0.0001566787,0.0002432915,0.0001907812,0.00002035972,0.0001720308,0.0000685748,0.0007843795,0.9516921,0.007812462,0.001242508,0.03707844],"study_design_scores_gemma":[0.000183218,0.0008955817,0.0005980457,0.00001443285,0.0000203811,0.000282453,0.00002797957,0.001582726,0.9752738,0.001077065,0.02002789,0.00001644114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691919,0.03706517,0.06370505,0.005237153,0.0008081825,0.0004041094,0.001098256,0.0008148548,0.02167541],"genre_scores_gemma":[0.9650792,0.009631872,0.01393695,0.001036879,0.0001262702,0.0001700206,0.0005971868,0.00003059094,0.009390926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002487006,"threshold_uncertainty_score":0.008319855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08559728218779089,"score_gpt":0.3535175244373098,"score_spread":0.2679202422495189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}