{"id":"W2088983697","doi":"10.1002/mc.10031","title":"Mutations in conserved regions 1, 2, and 3 of Raf‐1 that activate transforming activity","year":2002,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Biology; Mutant; Kinase; MAPK/ERK pathway; Effector; Mutation; Protein kinase A; Protein kinase domain; Cell biology; Molecular biology; Two-hybrid screening; Yeast; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014583,0.0001258163,0.0001553068,0.0001010608,0.00005455985,0.000009351709,0.00006787164,0.0001060952,0.00001496367],"category_scores_gemma":[0.00003330598,0.000135731,0.00009285872,0.0001488997,0.00008873631,0.000006789616,0.00003084639,0.00004982992,6.739952e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001124036,"about_ca_system_score_gemma":0.00002083019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007732422,"about_ca_topic_score_gemma":0.00005652159,"domain_scores_codex":[0.9992341,0.00009167513,0.0001448441,0.0002499822,0.0001116212,0.0001677183],"domain_scores_gemma":[0.999609,0.00001208791,0.00006534895,0.0002123048,0.00003759865,0.00006364114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003049026,0.0000458028,0.004484274,0.00003028197,0.00002541364,0.00001446416,0.00008668198,0.0001422529,0.9908991,0.0001149901,0.000009021995,0.004117186],"study_design_scores_gemma":[0.0006421279,0.00004444952,0.01031821,0.00002387964,0.00002441114,0.00001674752,0.00004876708,0.000587092,0.9877359,0.00007362395,0.0003401087,0.0001447335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876062,0.001805624,0.009767883,0.0002576561,0.00001560966,0.0002369022,0.00001615995,0.000007863855,0.0002860785],"genre_scores_gemma":[0.9991574,0.0001439256,0.0004862605,0.00007156639,0.00001069391,0.00003208686,0.00001734179,0.00001802695,0.00006274854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01155113,"threshold_uncertainty_score":0.553495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772293718515231,"score_gpt":0.2351748907192399,"score_spread":0.2074519535340876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}