{"id":"W2088983697","doi":"10.1002/mc.10031","title":"Mutations in conserved regions 1, 2, and 3 of Raf‐1 that activate transforming activity","year":2002,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Biology; Mutant; Kinase; MAPK/ERK pathway; Effector; Mutation; Protein kinase A; Protein kinase domain; Cell biology; Molecular biology; Two-hybrid screening; Yeast; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247867,0.0005354211,0.0002076311,0.0002129824,0.0001565123,0.000153511,0.0002374514,0.0002694401,0.001226732],"category_scores_gemma":[0.0001561644,0.0001413627,0.0003919523,0.0001338422,0.0002361567,0.00008944218,0.0001606235,0.0004763576,0.0004223857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855285,"about_ca_system_score_gemma":0.0002319419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006662904,"about_ca_topic_score_gemma":0.001167252,"domain_scores_codex":[0.9998946,0.00001912314,0.00001013091,0.00001951992,0.0000312237,0.00002534683],"domain_scores_gemma":[0.9998907,0.00002364665,0.00003697673,0.00001211079,0.000007024378,0.00002951074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001335672,0.00004209448,0.0005972681,0.00001667803,0.00000823419,0.0002580553,0.00001463199,0.0001626549,0.9976177,0.00009880648,0.00002714707,0.001023131],"study_design_scores_gemma":[0.00009912035,0.0004701116,0.01618246,0.00001249819,0.00003542827,0.003134732,0.00003527615,0.001438575,0.9758915,0.000111323,0.002569331,0.00001959571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982969,0.0002193662,0.0006233594,0.00002201802,0.000008199693,0.00002328096,0.0001569345,0.0000358194,0.0006141088],"genre_scores_gemma":[0.9978247,0.0001657361,0.001126956,0.00002216756,0.000003602822,0.00001797301,0.0002811316,0.0000148797,0.0005428591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226732,"threshold_uncertainty_score":0.00410378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772293718515231,"score_gpt":0.2351748907192399,"score_spread":0.2074519535340876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}