{"id":"W2088984315","doi":"10.1016/j.chembiol.2011.09.014","title":"Ca2+-Mediated Synthetic Biosystems Offer Protein Design Versatility, Signal Specificity, and Pathway Rewiring","year":2011,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"RHOA; Cell biology; Calmodulin; Chimera (genetics); Signal transduction; Biology; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997544,0.0002142427,0.0002222927,0.00004049793,0.0001153196,0.00002687314,0.0003328917,0.0001413952,0.0001007514],"category_scores_gemma":[0.0003993984,0.0001855726,0.00004164614,0.0002037822,0.0003521364,0.00009374241,0.0001589165,0.0002261764,0.00003401398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002840158,"about_ca_system_score_gemma":0.0000357065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001276408,"about_ca_topic_score_gemma":3.292603e-7,"domain_scores_codex":[0.9984519,0.00009340527,0.000244615,0.0006673624,0.0001097589,0.0004329027],"domain_scores_gemma":[0.9992912,0.0001811308,0.0000819146,0.0002819197,0.00001816641,0.0001457074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002858422,0.0000320826,0.0001936765,0.0000504094,0.000001436802,0.0000454051,0.00009481348,0.000001504174,0.9990907,0.00006445678,0.000005052926,0.0003918899],"study_design_scores_gemma":[0.0001678735,0.0000844409,0.0001022121,0.00003243544,0.000003294581,0.00006931357,0.00001954855,0.0009184371,0.9977582,0.0002037881,0.0004445777,0.0001959136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972747,0.00006979429,0.0006043179,0.0000346122,0.000153001,0.0002702182,0.00001872346,0.0001515824,0.001423072],"genre_scores_gemma":[0.9995345,0.0000251379,0.00008620762,0.00006827045,0.0000632965,0.00003012922,0.000001583827,0.00001815435,0.0001726889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002259853,"threshold_uncertainty_score":0.7567432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08088039305123565,"score_gpt":0.231123544232043,"score_spread":0.1502431511808073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}