{"id":"W2088985649","doi":"10.1210/me.2006-0452","title":"CCAAT/Enhancer Binding Protein β Abrogates Retinoic Acid-Induced Osteoblast Differentiation via Repression of Runx2 Transcription","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; University of Ottawa; McKnight Foundation","keywords":"RUNX2; Ccaat-enhancer-binding proteins; Retinoic acid; Osteoblast; Biology; Transcription factor; Molecular biology; Enhancer; Cellular differentiation; Osteocalcin; Promoter; Retinoic acid receptor; Core binding factor; Cell biology; Gene expression; Alkaline phosphatase; Biochemistry; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361357,0.0002414406,0.0002721322,0.0001575385,0.00007949566,0.00001249052,0.0002005572,0.0002167304,0.00004646337],"category_scores_gemma":[0.00009761733,0.0002359273,0.000180942,0.0001523968,0.00009247953,0.00001013457,0.00009971941,0.0001305803,0.00001274774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001615733,"about_ca_system_score_gemma":0.000035752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003572095,"about_ca_topic_score_gemma":0.00002662076,"domain_scores_codex":[0.9982184,0.000135795,0.0004282576,0.0005239192,0.0001995804,0.0004941139],"domain_scores_gemma":[0.9990794,0.000008262474,0.0002113288,0.0004779006,0.0001166289,0.000106473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309509,0.0001315358,0.000480826,0.0000511222,0.00005498945,0.00002336505,0.00003786081,0.0000055011,0.9917199,0.0002427141,0.00002308799,0.006898149],"study_design_scores_gemma":[0.001029695,0.0002764625,0.003347234,0.00003447641,0.00006142979,0.00002283939,0.00005560486,0.00001210027,0.994266,0.0001402122,0.0005271612,0.0002267239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827208,0.001412661,0.01464859,0.00006474803,0.0002403035,0.0004031853,0.0000143946,0.00003793279,0.0004574135],"genre_scores_gemma":[0.9987834,0.00006465671,0.0005725588,0.00002723972,0.000101726,0.00004799067,0.0002108234,0.00003602193,0.0001555919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01606262,"threshold_uncertainty_score":0.9620835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008105791723720805,"score_gpt":0.2483803655658169,"score_spread":0.2402745738420961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}