{"id":"W2088985649","doi":"10.1210/me.2006-0452","title":"CCAAT/Enhancer Binding Protein β Abrogates Retinoic Acid-Induced Osteoblast Differentiation via Repression of Runx2 Transcription","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; University of Ottawa; McKnight Foundation","keywords":"RUNX2; Ccaat-enhancer-binding proteins; Retinoic acid; Osteoblast; Biology; Transcription factor; Molecular biology; Enhancer; Cellular differentiation; Osteocalcin; Promoter; Retinoic acid receptor; Core binding factor; Cell biology; Gene expression; Alkaline phosphatase; Biochemistry; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679326,0.0004701568,0.0003748322,0.0003946428,0.0001663857,0.0002521033,0.0002850409,0.0002164749,0.002043222],"category_scores_gemma":[0.0001163315,0.0002402066,0.0003307109,0.0001824527,0.00038214,0.0001135919,0.0002040665,0.0009071019,0.0005611674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241462,"about_ca_system_score_gemma":0.0005512825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002240377,"about_ca_topic_score_gemma":0.002674273,"domain_scores_codex":[0.9997086,0.00004298753,0.00002704004,0.00003559393,0.00009757942,0.00008818812],"domain_scores_gemma":[0.999853,0.00002908345,0.00004126423,0.0000182126,0.00001370139,0.00004474331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001677622,0.00004712896,0.00007421148,0.00002445538,0.000005547303,0.00003752664,0.00001103057,0.00005446884,0.9987771,0.00007995481,0.00004101271,0.0006797864],"study_design_scores_gemma":[0.00004243648,0.0004035799,0.00216301,0.00000639348,0.00001798792,0.0001326404,0.00002369204,0.0007345512,0.993754,0.00003735796,0.002679911,0.000004466528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909742,0.00214945,0.00214446,0.0002172365,0.00008983057,0.00004160132,0.0005626996,0.0002029472,0.003617572],"genre_scores_gemma":[0.9913436,0.001589591,0.001120876,0.00009597211,0.00002653123,0.00006312128,0.0007910089,0.00005333844,0.004915998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002240377,"threshold_uncertainty_score":0.006835222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008105791723720805,"score_gpt":0.2483803655658169,"score_spread":0.2402745738420961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}