{"id":"W2089027583","doi":"10.1515/bc.2008.121","title":"Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; “la Caixa” Foundation; Canadian Institute for Theoretical Astrophysics","keywords":"Metalloproteinase; Stable isotope labeling by amino acids in cell culture; Matrix metalloproteinase; Tumor progression; Chemistry; ADAM10; Cleavage (geology); Cell culture; Tumor cells; ADAMTS; Metastasis; Biochemistry; Cell biology; Cancer research; Biology; Proteomics; Disintegrin; Thrombospondin; Gene; Cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963898,0.0006887197,0.0003286604,0.000808758,0.0004198204,0.0004163214,0.0002757703,0.0004001849,0.001607889],"category_scores_gemma":[0.000263071,0.0001827539,0.0004643597,0.0003290077,0.0003099018,0.0002521031,0.0002107379,0.0005391596,0.000541479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000620163,"about_ca_system_score_gemma":0.0004817794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526781,"about_ca_topic_score_gemma":0.001914402,"domain_scores_codex":[0.9998568,0.00001940526,0.00001046171,0.00002926251,0.00004739688,0.00003653675],"domain_scores_gemma":[0.999806,0.00003220653,0.00005504412,0.00001660863,0.00004285328,0.00004725519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007471609,0.00001036056,0.0006570318,0.00003803898,0.00001115154,0.0001268836,0.000006319644,0.00006039135,0.9967341,0.00007900244,0.00005076938,0.002151241],"study_design_scores_gemma":[0.000007052543,0.0001179138,0.007077955,0.000005289308,0.00001962083,0.0008799539,0.00002131482,0.0007603519,0.988233,0.00009781504,0.002771651,0.000008086574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767843,0.006201367,0.01335951,0.0002905086,0.00007146592,0.00007275184,0.001091961,0.0001341969,0.001994005],"genre_scores_gemma":[0.9549946,0.003817743,0.03173323,0.0001186635,0.00004350073,0.00007997057,0.002872495,0.00004078028,0.006299114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607889,"threshold_uncertainty_score":0.005378962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269062762964376,"score_gpt":0.2431306566541135,"score_spread":0.2104400290244698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}