{"id":"W2089027583","doi":"10.1515/bc.2008.121","title":"Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; “la Caixa” Foundation; Canadian Institute for Theoretical Astrophysics","keywords":"Metalloproteinase; Stable isotope labeling by amino acids in cell culture; Matrix metalloproteinase; Tumor progression; Chemistry; ADAM10; Cleavage (geology); Cell culture; Tumor cells; ADAMTS; Metastasis; Biochemistry; Cell biology; Cancer research; Biology; Proteomics; Disintegrin; Thrombospondin; Gene; Cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001270561,0.0001928124,0.0004110801,0.00001730289,0.0001216242,0.00001093809,0.00007015265,0.0002817089,0.00101758],"category_scores_gemma":[0.0004174397,0.0001377289,0.0001621678,0.0001814976,0.000241548,0.00002558182,0.00005138152,0.0002645839,0.00002606636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005336068,"about_ca_system_score_gemma":0.00003895295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001743405,"about_ca_topic_score_gemma":7.643791e-7,"domain_scores_codex":[0.9988521,0.00004453386,0.0002686375,0.0003763174,0.0001831893,0.0002752485],"domain_scores_gemma":[0.999339,0.00003598006,0.0001008913,0.00018786,0.00007376752,0.0002625141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001052456,0.0003051999,0.003411195,0.00002875186,0.0001092805,0.0001009418,0.00001680245,4.933691e-8,0.988261,0.000003056735,0.007190648,0.0004678225],"study_design_scores_gemma":[0.002765063,0.0002249682,0.01128751,0.0002187639,0.0001009717,0.0001565096,0.0001396011,0.00009434148,0.976166,0.00006871011,0.008381335,0.0003962154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957248,0.0003967588,0.00002464015,0.0007858542,0.000003504967,0.0001510775,0.0000964498,0.0001336111,0.00268329],"genre_scores_gemma":[0.9952461,0.00008778429,0.0002271162,0.0005743337,0.00007343759,0.00003966823,0.000451269,0.00001016417,0.00329009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.012095,"threshold_uncertainty_score":0.9998956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269062762964376,"score_gpt":0.2431306566541135,"score_spread":0.2104400290244698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}