{"id":"W2089052972","doi":"10.1371/journal.pone.0049934","title":"A Novel Bioassay for the Activity Determination of Therapeutic Human Brain Natriuretic Peptide (BNP)","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Institutes for Food and Drug Control","keywords":"Bioassay; Natriuretic peptide; Potency; Pharmacology; Recombinant DNA; Brain natriuretic peptide; Stimulation; Receptor; Cell culture; Peptide; Medicine; Biology; Internal medicine; In vitro; Biochemistry; Heart failure; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002014552,0.001554761,0.0007998073,0.001031311,0.0003580576,0.0006645999,0.001027574,0.001451293,0.001413197],"category_scores_gemma":[0.00154554,0.0004008722,0.0006994401,0.0006508949,0.0006339028,0.0005343444,0.0006826649,0.001966282,0.001227448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985535,"about_ca_system_score_gemma":0.0007671918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002396092,"about_ca_topic_score_gemma":0.0006190594,"domain_scores_codex":[0.9965293,0.0009225964,0.0002678386,0.0006881601,0.001429772,0.0001622447],"domain_scores_gemma":[0.9987092,0.0004304925,0.0002468401,0.0001785286,0.0003077807,0.0001272024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006685283,0.0001189316,0.0005555972,0.0001221551,0.00001961556,0.0000340316,0.00002170108,0.00008977844,0.9937912,0.0001355042,0.000124536,0.004920124],"study_design_scores_gemma":[0.00003923602,0.001141723,0.003977194,0.00003955794,0.0001107563,0.0008673929,0.00003519675,0.00351938,0.9840091,0.0002381003,0.005982024,0.00004029716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.228249,0.01018585,0.7505383,0.0005551873,0.0009634841,0.001531694,0.002224253,0.001230424,0.004521792],"genre_scores_gemma":[0.4282788,0.005009512,0.5531225,0.0006574442,0.0004468802,0.002182827,0.003626933,0.0001055074,0.006569563],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002014552,"threshold_uncertainty_score":0.01065409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09915166240786069,"score_gpt":0.3132691354967115,"score_spread":0.2141174730888508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}