{"id":"W2089065337","doi":"10.1021/ja207173p","title":"Protein Conformational Gating of Enzymatic Activity in Xanthine Oxidoreductase","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Chemistry; Flavin group; NAD+ kinase; Xanthine dehydrogenase; Oxidoreductase; Semiquinone; Cofactor; Stereochemistry; Redox; Xanthine oxidase; Enzyme; Biochemistry; Quinone; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000262648,0.00007231003,0.0001829613,0.000009661713,0.00001847152,0.000002877805,0.0002292612,0.00003491957,0.00001076709],"category_scores_gemma":[0.0001669455,0.00004855257,0.0002252474,0.0001202328,0.0002680868,0.000008164641,0.00007697009,0.0001492343,2.822676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001190603,"about_ca_system_score_gemma":0.00008619441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004858843,"about_ca_topic_score_gemma":7.756112e-7,"domain_scores_codex":[0.9993594,0.0000403199,0.0002708069,0.00006188356,0.0001570639,0.0001104728],"domain_scores_gemma":[0.9991338,0.00001063456,0.0006270029,0.0001236227,0.00006550016,0.0000393946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008322272,0.0001070629,0.002153798,0.0000170387,0.00003294762,1.990993e-7,0.0002893916,0.000006220524,0.996136,0.00001868015,0.0003760313,0.0007794508],"study_design_scores_gemma":[0.0003829634,0.00005429149,0.01111666,0.00002148003,0.00001249789,0.00001130731,0.0004249538,0.0000516532,0.9875287,0.0002295802,0.0001047832,0.00006106161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993082,0.00009083744,0.0002051196,0.0001216378,0.00002693387,0.00006216477,0.000005452108,9.819826e-7,0.0001786927],"genre_scores_gemma":[0.9941624,0.00002866942,0.005556647,0.0001781024,0.0000564164,0.000002058178,0.000001344219,0.000004956884,0.000009346641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008962859,"threshold_uncertainty_score":0.1979917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053614225722081,"score_gpt":0.2388729944145029,"score_spread":0.2283368521572821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}