{"id":"W2089065337","doi":"10.1021/ja207173p","title":"Protein Conformational Gating of Enzymatic Activity in Xanthine Oxidoreductase","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Chemistry; Flavin group; NAD+ kinase; Xanthine dehydrogenase; Oxidoreductase; Semiquinone; Cofactor; Stereochemistry; Redox; Xanthine oxidase; Enzyme; Biochemistry; Quinone; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402471,0.0001460244,0.0001767365,0.00006481075,0.0001515898,0.0003174921,0.0002913239,0.0002217086,0.001048512],"category_scores_gemma":[0.0002654431,0.000137853,0.0001753042,0.0001145956,0.0003518698,0.0003823294,0.0001914669,0.0004399725,0.0001449335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257829,"about_ca_system_score_gemma":0.0001029685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004305296,"about_ca_topic_score_gemma":0.0004465239,"domain_scores_codex":[0.9999409,0.000007290937,0.000003293292,0.00001972531,0.00001410981,0.00001475048],"domain_scores_gemma":[0.9999349,0.00002150143,0.00001477441,0.000004544806,0.000007509372,0.00001668967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005384971,0.00007511085,0.005488602,0.0001249017,0.00003849308,0.0004841753,0.0002519602,0.003306523,0.9810627,0.002127404,0.0002148043,0.006286862],"study_design_scores_gemma":[0.0002477203,0.0008015604,0.1018539,0.00004519818,0.00007844104,0.001556733,0.0005774171,0.1019724,0.7827486,0.004856429,0.005137082,0.0001244362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970326,0.0003628971,0.001800086,0.00007926122,0.0000101986,0.000005215509,0.00004934313,0.00003366456,0.0006266967],"genre_scores_gemma":[0.9991702,0.0001691644,0.0003146417,0.00002469796,0.000002611829,0.000003779627,0.00007506325,0.000007893384,0.0002318846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048512,"threshold_uncertainty_score":0.003507614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053614225722081,"score_gpt":0.2388729944145029,"score_spread":0.2283368521572821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}