{"id":"W2089092612","doi":"10.1134/s0006297910050056","title":"Mechanism of steroidogenic electron transport: Role of conserved Glu429 in destabilization of CYP11A1-Adrenodoxin complex","year":2010,"lang":"en","type":"article","venue":"Biochemistry (Moscow)","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Adrenodoxin; Cholesterol side-chain cleavage enzyme; Chemistry; Hemeprotein; Cytochrome; Ionic strength; Cytochrome c; Electron transport chain; Biophysics; Mutant; Dissociation (chemistry); Stereochemistry; Cytochrome P450; Biochemistry; Enzyme; Mitochondrion; Heme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005479376,0.0002403699,0.0005009304,0.00009596872,0.00004125805,0.000002430868,0.0003946848,0.0004169678,0.0009642615],"category_scores_gemma":[0.00005506912,0.0002633773,0.0001432196,0.0002924023,0.0002876353,0.00003670101,0.00005069374,0.0004853456,0.00000297838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002025141,"about_ca_system_score_gemma":0.0001805677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007227618,"about_ca_topic_score_gemma":0.00008350548,"domain_scores_codex":[0.9981854,0.0001383466,0.0008095151,0.0003142184,0.0002014321,0.0003510679],"domain_scores_gemma":[0.9987977,0.000111951,0.0004397427,0.0003177877,0.0001841925,0.0001486909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003609329,0.0006017726,0.012283,0.000250952,0.00006936996,0.000002663419,0.00035032,0.00007134901,0.9842641,0.0008025265,0.00002633636,0.0009167076],"study_design_scores_gemma":[0.002040822,0.00007172381,0.003798479,0.00001788976,0.0001472833,0.000007864995,0.00009449854,0.0009904766,0.9903805,0.0007901729,0.001454629,0.0002056873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964245,0.00109039,0.00005486288,0.00004503251,0.0002420025,0.0003119799,0.0003222736,0.00001984193,0.001489108],"genre_scores_gemma":[0.9989592,0.0002408539,0.0004456958,0.00005537075,0.00006350093,0.0000190151,0.0001255796,0.00002798931,0.00006280708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008484516,"threshold_uncertainty_score":0.9999818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04941577240373465,"score_gpt":0.3619158691488349,"score_spread":0.3125000967451003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}