{"id":"W2089114270","doi":"10.1038/ni.1974","title":"Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes","year":2010,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"KWF Kankerbestrijding; Stichting Vanderes","keywords":"Epitope; CTL*; Cytotoxic T cell; Antigen; Biology; Virology; MHC class I; Antigen processing; Linear epitope; Chemistry; Major histocompatibility complex; Molecular biology; Cell biology; Immunology; Biochemistry; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576086,0.0002058061,0.0003763367,0.0001962526,0.0001719186,0.00004881086,0.00009927272,0.0006582767,0.0003877532],"category_scores_gemma":[0.00009874683,0.0001644423,0.00009621289,0.0002789695,0.0002281017,0.0001111203,0.00005770259,0.001344964,0.00005994899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552104,"about_ca_system_score_gemma":0.00007468138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002091489,"about_ca_topic_score_gemma":0.0000126146,"domain_scores_codex":[0.9989055,0.00005385379,0.0002342414,0.0003653208,0.0001408904,0.0003001266],"domain_scores_gemma":[0.9993361,0.00003667442,0.0001044457,0.0002741826,0.0001445194,0.0001041133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004640508,0.0001169579,0.001922786,0.0000240945,0.00007089621,0.00004201118,0.0000928695,1.536011e-7,0.9874816,0.00008805818,0.002997006,0.007117154],"study_design_scores_gemma":[0.001084437,0.0001073876,0.003513893,0.00007296474,0.00006328277,0.0002422672,0.0001367663,0.0001461908,0.9425346,0.0001569591,0.05172575,0.0002155134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837045,0.01089816,0.0000367864,0.002638426,0.00008349607,0.0001381482,0.00002234618,0.00009933885,0.00237879],"genre_scores_gemma":[0.9947022,0.0003834571,0.001517283,0.001744461,0.0002013251,0.00001148752,0.0001415634,0.00002514907,0.001273098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04872874,"threshold_uncertainty_score":0.6705763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002592137909453106,"score_gpt":0.2422788777956015,"score_spread":0.2396867398861484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}