{"id":"W2089127461","doi":"10.1016/j.bmc.2003.08.003","title":"Semisynthetic modifications of hemiaminal function at ornithine unit of mulundocandin, towards chemical stability and antifungal activity","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Hemiaminal; Aspergillus fumigatus; In vivo; Candida albicans; Stereochemistry; Nucleophile; Microbiology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009327455,0.0002288461,0.000105755,0.000118099,0.0001030944,0.0001271413,0.0002119092,0.0001550986,0.0007660306],"category_scores_gemma":[0.000153329,0.00006408731,0.0001502808,0.0001442024,0.0001635553,0.0002467654,0.0001544086,0.0003672195,0.0001516378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001590374,"about_ca_system_score_gemma":0.0001690782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002671716,"about_ca_topic_score_gemma":0.0003972284,"domain_scores_codex":[0.9999528,0.000008789908,0.000005796564,0.00001010452,0.000007991525,0.00001448997],"domain_scores_gemma":[0.9999216,0.00001109197,0.00003077372,0.00001313832,0.00001014198,0.00001334014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422315,0.00003910199,0.0001476066,0.00004162484,0.0000052798,0.0001080437,0.00002329735,0.0002073007,0.9954732,0.0002883113,0.00002632351,0.003397755],"study_design_scores_gemma":[0.0000144503,0.0002417301,0.000834548,0.000004494221,0.00001064759,0.0001194917,0.00001212183,0.0002238462,0.9969771,0.00005822384,0.001498429,0.000004855317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995611,0.0006868693,0.002429244,0.0000445283,0.0000263342,0.00001500471,0.00009148025,0.00002453197,0.001070923],"genre_scores_gemma":[0.997225,0.0002911908,0.001361942,0.00002125047,0.00000452249,0.000006935863,0.000113402,0.000009109936,0.0009666587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007660306,"threshold_uncertainty_score":0.002562642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03041695618437793,"score_gpt":0.268084300103177,"score_spread":0.2376673439187991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}