{"id":"W2089132167","doi":"10.1002/cmdc.200800168","title":"The Discovery of Pyrano[3,4‐<i>b</i>]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Hepatitis C virus research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; KMT Hepatech (Canada)","funders":"","keywords":"NS5B; Subgenomic mRNA; Indole test; In vivo; Virology; Hepatitis C virus; Polymerase; Replicon; Sofosbuvir; Biology; Chemistry; Stereochemistry; Enzyme; Hepacivirus; Biochemistry; Gene; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002821313,0.0001893586,0.0004805693,0.0001479645,0.00007647986,0.000008425463,0.0001888048,0.0001086494,0.00004379986],"category_scores_gemma":[0.000245151,0.0001289355,0.0001165126,0.00063759,0.0007340556,0.0001568387,0.00007516581,0.0003265708,0.000004670504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001193102,"about_ca_system_score_gemma":0.0006299688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000701778,"about_ca_topic_score_gemma":0.0002148176,"domain_scores_codex":[0.9981411,0.00007202923,0.0003711408,0.0002772918,0.0007336341,0.0004047835],"domain_scores_gemma":[0.9987158,0.0003168032,0.0001594968,0.0005476837,0.0001223981,0.0001378043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001783683,0.0005958603,0.1272465,0.0002646909,0.00006219636,0.0001538209,0.0005217046,0.000002923246,0.8593358,0.000008530153,0.0005988855,0.009425327],"study_design_scores_gemma":[0.002653608,0.0003235207,0.01609014,0.0002437106,0.00001911533,0.00001206419,0.00008541728,0.0001333427,0.9797202,0.000003314217,0.0005919582,0.0001236533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929653,0.0003242293,0.00003688365,0.0008178899,0.00003811746,0.0004276946,0.00002351122,0.00001818697,0.005348226],"genre_scores_gemma":[0.9988257,0.0001377864,0.000104401,0.0001131688,0.00005991593,0.0000464757,0.000005901291,0.00003774596,0.0006688541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1203843,"threshold_uncertainty_score":0.5257838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296368109981041,"score_gpt":0.2817880959370843,"score_spread":0.2521512849389801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}