{"id":"W2089132167","doi":"10.1002/cmdc.200800168","title":"The Discovery of Pyrano[3,4‐<i>b</i>]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Hepatitis C virus research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; KMT Hepatech (Canada)","funders":"","keywords":"NS5B; Subgenomic mRNA; Indole test; In vivo; Virology; Hepatitis C virus; Polymerase; Replicon; Sofosbuvir; Biology; Chemistry; Stereochemistry; Enzyme; Hepacivirus; Biochemistry; Gene; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257527,0.0002586599,0.0001446632,0.0001466851,0.0001113836,0.0001930916,0.000218174,0.0001989825,0.001094973],"category_scores_gemma":[0.00008630817,0.0001010536,0.0001456254,0.00007881157,0.0001335942,0.0001187153,0.000101469,0.0003816374,0.0002509297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002956074,"about_ca_system_score_gemma":0.0002085641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005842761,"about_ca_topic_score_gemma":0.001363332,"domain_scores_codex":[0.9999611,0.000007379886,0.00000216711,0.000004759055,0.00001063127,0.00001402587],"domain_scores_gemma":[0.9999672,0.000004260583,0.000007834259,0.000002381064,0.000007144244,0.00001115282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376812,0.0001466897,0.0002623745,0.0001183646,0.00000785409,0.0001366248,0.00003843351,0.0007632956,0.97552,0.0009754492,0.0003370072,0.02145606],"study_design_scores_gemma":[0.0002184994,0.002454963,0.002138037,0.00002942316,0.00003717546,0.0005613143,0.00002152507,0.002657689,0.9712726,0.0002711069,0.02032132,0.00001630295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462366,0.01600586,0.02087763,0.0005966493,0.0001323644,0.0002398145,0.0005529103,0.0003409696,0.01501724],"genre_scores_gemma":[0.9821406,0.007060794,0.006282114,0.0001578378,0.00003606091,0.00005391358,0.0003922581,0.0000199754,0.00385651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094973,"threshold_uncertainty_score":0.003663003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296368109981041,"score_gpt":0.2817880959370843,"score_spread":0.2521512849389801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}