{"id":"W2089147191","doi":"10.1124/dmd.104.003186","title":"METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Metabolite; Chemistry; Metabolism; Pharmacology; Doxorubicin; Biochemistry; Hepatocyte; Drug metabolism; Myocyte; Endocrinology; Internal medicine; Biology; Medicine; Anthracycline; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004076517,0.0002718492,0.0008218273,0.000125233,0.0001478527,0.00002849467,0.00007210011,0.0001371071,0.00001525341],"category_scores_gemma":[0.00006281694,0.0002108085,0.0001569753,0.0002954701,0.0002395836,0.0003276464,0.00006813775,0.0002346085,6.595665e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001401294,"about_ca_system_score_gemma":0.00005491835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001924836,"about_ca_topic_score_gemma":0.00001643492,"domain_scores_codex":[0.9984076,0.0001867032,0.0004393403,0.0003798071,0.0003568419,0.0002297197],"domain_scores_gemma":[0.9990122,0.0000740787,0.0002532951,0.0002874294,0.0002182846,0.0001547076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003042982,0.0001913067,0.0004470026,0.000217767,0.000401737,9.018722e-7,0.001900089,0.000002536398,0.9807101,0.0020581,0.0000645732,0.01370159],"study_design_scores_gemma":[0.003502936,0.00003410781,0.0297921,0.0001554137,0.001839405,0.0000680943,0.0002316116,0.0001713827,0.9615501,0.00031156,0.002145999,0.0001972902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8920338,0.1057826,0.000115377,0.0007459301,0.00007864863,0.0008787206,0.00016756,0.00002976837,0.0001675731],"genre_scores_gemma":[0.9890926,0.009605755,0.0005085223,0.0002697004,0.0001958623,0.00004237228,0.0000578558,0.00002841988,0.0001988636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09705884,"threshold_uncertainty_score":0.8596519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005168757657992715,"score_gpt":0.2072040611576532,"score_spread":0.2020353034996605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}