{"id":"W2089164477","doi":"10.1038/sj.bjc.6600459","title":"Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines","year":2002,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Methionine; Methylenetetrahydrofolate reductase; Biology; Methionine synthase; Reductase; Cancer research; Molecular biology; Homocysteine; Cell culture; Biochemistry; Enzyme; Genetics; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303202,0.0002894364,0.0003320897,0.0001882537,0.0001089417,0.0002077553,0.0001770513,0.0002564762,0.001275671],"category_scores_gemma":[0.0001320613,0.0001336964,0.000228403,0.0001240515,0.0001354581,0.0001064148,0.0001282589,0.0004406621,0.000282888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876864,"about_ca_system_score_gemma":0.0002039733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700526,"about_ca_topic_score_gemma":0.002672693,"domain_scores_codex":[0.9998571,0.00001934794,0.00001983293,0.00003347457,0.00004426555,0.00002605461],"domain_scores_gemma":[0.9998191,0.00005327955,0.00003715782,0.00001730372,0.00002951628,0.00004359695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005200128,0.00001934618,0.00007074933,0.00001299334,0.000003522523,0.00001234955,0.00001144576,0.00002495349,0.9993255,0.00001940601,0.00001915313,0.0004284595],"study_design_scores_gemma":[0.00001040128,0.0007347637,0.003066603,0.000003445169,0.00001496044,0.00009411691,0.0000267932,0.0005494793,0.9943715,0.00001095447,0.001114507,0.000002437054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959807,0.001315091,0.00132126,0.00006270713,0.00002947318,0.00001951746,0.0002501207,0.00007924104,0.0009418345],"genre_scores_gemma":[0.9894518,0.001574899,0.001898939,0.00005859696,0.000009449966,0.00004571704,0.001027317,0.00003045266,0.005902769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700526,"threshold_uncertainty_score":0.004267514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03999828002745998,"score_gpt":0.3319815268229206,"score_spread":0.2919832467954607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}