{"id":"W2089185946","doi":"10.1371/journal.pone.0124903","title":"The Anti-Inflammatory Activity of Curcumin Protects the Genital Mucosal Epithelial Barrier from Disruption and Blocks Replication of HIV-1 and HSV-2","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"McMaster University; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research","keywords":"Curcumin; Proinflammatory cytokine; Occludin; Chemokine; Biology; Tumor necrosis factor alpha; Immunology; Interleukin 8; Tight junction; Inflammation; Pharmacology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075565,0.00007163083,0.0001389472,0.00002056703,0.0001216281,0.000008012481,0.00007956681,0.00007614876,0.00001384944],"category_scores_gemma":[0.0002453012,0.00004052843,0.00001983371,0.00003271151,0.0003853105,0.00005063206,0.00007349329,0.0001290697,0.00002223565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001381976,"about_ca_system_score_gemma":0.00005296032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001317945,"about_ca_topic_score_gemma":0.00003153221,"domain_scores_codex":[0.9993342,0.000186272,0.0001242984,0.0001648888,0.00006378519,0.0001265932],"domain_scores_gemma":[0.9993041,0.000175152,0.00009605027,0.0003201,0.00007765051,0.00002699406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000333412,0.0002763194,0.02247258,0.0000150134,0.0002960898,8.742264e-7,0.0006463849,8.76932e-8,0.9705168,0.00003569392,0.00005085835,0.005355871],"study_design_scores_gemma":[0.001039871,0.0002128947,0.09806588,0.00002221201,0.00006884481,0.000003745389,0.000142267,0.00002279425,0.8999674,0.0001802185,0.0002273984,0.00004642771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99732,0.001379556,0.00002517866,0.0004187557,0.00001607621,0.0005112565,0.0002483789,0.000009775075,0.00007102329],"genre_scores_gemma":[0.9994907,0.0001099657,0.00003469775,0.000002875378,0.0000207831,0.00006014422,0.00004099497,0.000005301094,0.0002345346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0755933,"threshold_uncertainty_score":0.1652701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152969214364462,"score_gpt":0.2466165829350093,"score_spread":0.2150868907913646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}