{"id":"W2089195565","doi":"10.1002/cncr.20168","title":"Oral topotecan in children with recurrent or progressive high‐grade glioma","year":2004,"lang":"en","type":"article","venue":"Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deutsche Kinderkrebsstiftung","keywords":"Topotecan; Medicine; Pharmacokinetics; Glioma; Toxicity; Gastroenterology; Surgery; Internal medicine; Chemotherapy; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122127,0.000345417,0.0008035799,0.0002234551,0.0003034018,0.0002738958,0.0002249275,0.0003241644,0.0006402745],"category_scores_gemma":[0.0004213096,0.0001156392,0.0002863314,0.0004397907,0.0003376321,0.000220672,0.00020501,0.0005030229,0.0001860339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006912796,"about_ca_system_score_gemma":0.0009155872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005170522,"about_ca_topic_score_gemma":0.007377549,"domain_scores_codex":[0.9998515,0.00003107863,0.0000119387,0.00002357052,0.00003695628,0.00004495861],"domain_scores_gemma":[0.9997471,0.00004223557,0.00009768663,0.000009619603,0.00001895901,0.00008440185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.004255818,0.0006411613,0.8195814,0.0006810238,0.0002201348,0.03423396,0.0009043523,0.001177856,0.01901452,0.0002806897,0.003463282,0.1155457],"study_design_scores_gemma":[0.0007948698,0.01339312,0.857696,0.0001109418,0.0004259038,0.1062173,0.0008248408,0.0009687601,0.008384084,0.0001609142,0.01099276,0.000030522],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954281,0.00306042,0.0001822269,0.0001085332,0.000007886293,0.00004810656,0.0001657213,0.00003159843,0.0009674212],"genre_scores_gemma":[0.9967435,0.002147995,0.0004691893,0.00007183909,0.00001597415,0.00003252535,0.0003454837,0.000006720146,0.0001668919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005170522,"threshold_uncertainty_score":0.01028085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835975801624504,"score_gpt":0.307219139205276,"score_spread":0.288859381189031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}