{"id":"W2089274221","doi":"10.1371/journal.pgen.1002696","title":"Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes","year":2012,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Bernische Krebsliga; Terry Fox Foundation; National Science Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Telomerase; Telomere; Biology; Telomerase reverse transcriptase; Haematopoiesis; Stem cell; Senescence; Dyskeratosis congenita; Telomerase RNA component; Immunology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926256,0.000250031,0.0002034565,0.0007704555,0.0001774092,0.0001785026,0.0001170463,0.0001758161,0.0007614035],"category_scores_gemma":[0.0004706407,0.0001552171,0.000144494,0.0003294038,0.0002792317,0.0001133931,0.0002520206,0.0001730402,0.0001198493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025938,"about_ca_system_score_gemma":0.000095531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728397,"about_ca_topic_score_gemma":0.0004890377,"domain_scores_codex":[0.9998635,0.00002597452,0.00001983695,0.00003503199,0.00003405652,0.00002160365],"domain_scores_gemma":[0.9998034,0.00004386701,0.00007990084,0.00002702829,0.00001256917,0.00003341179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006892201,0.0000251209,0.0417408,0.00004846523,0.00006443658,0.002005738,0.0002121774,0.0003035862,0.946409,0.0004293317,0.00009166333,0.007980389],"study_design_scores_gemma":[0.00007886701,0.001439693,0.6154378,0.00003364447,0.0002234155,0.03490626,0.0003068105,0.002897787,0.3406471,0.001055297,0.002935844,0.0000375032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991269,0.0002196073,0.0004023273,0.000006378291,0.000001378446,0.000002404539,0.00008107867,0.00001204979,0.0001477625],"genre_scores_gemma":[0.9994068,0.0001035901,0.0002367892,0.0000055448,0.000001702782,0.000002199985,0.0001011026,0.000004377798,0.0001379777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007704555,"threshold_uncertainty_score":0.002547085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395642271662288,"score_gpt":0.2645009616508636,"score_spread":0.2405445389342407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}