{"id":"W2089274221","doi":"10.1371/journal.pgen.1002696","title":"Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes","year":2012,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Bernische Krebsliga; Terry Fox Foundation; National Science Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Telomerase; Telomere; Biology; Telomerase reverse transcriptase; Haematopoiesis; Stem cell; Senescence; Dyskeratosis congenita; Telomerase RNA component; Immunology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001998233,0.0003272142,0.0007102785,0.0005237243,0.00004975614,0.00001572081,0.0001846414,0.000206724,0.0001383107],"category_scores_gemma":[0.00009222292,0.0003289579,0.0001026354,0.001000556,0.0001888939,0.00009843428,0.0000668827,0.0002598859,0.00006360774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138708,"about_ca_system_score_gemma":0.000151635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006856305,"about_ca_topic_score_gemma":0.0001515411,"domain_scores_codex":[0.9974485,0.0001151827,0.0008398147,0.0003642412,0.0005053534,0.0007268884],"domain_scores_gemma":[0.9986011,0.0001830113,0.0001841868,0.0005538311,0.0001286409,0.0003492154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010448,0.002661682,0.3537235,0.0005794725,0.00008628386,0.000104933,0.005396182,0.00009147535,0.6327829,0.00002127736,0.0008489591,0.003602281],"study_design_scores_gemma":[0.002340893,0.0002376424,0.02709324,0.0002009053,0.0001403041,0.0000387621,0.001542609,0.0003890985,0.9664162,0.00003091882,0.00115004,0.0004193586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838137,0.01468776,0.00001410213,0.0002218522,0.0001802496,0.000761496,0.000122427,0.0000448736,0.000153515],"genre_scores_gemma":[0.9964778,0.00180146,0.001071614,0.0002116368,0.00009407334,0.0000698602,0.00006456231,0.0000673473,0.0001416864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3336333,"threshold_uncertainty_score":0.9999163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395642271662288,"score_gpt":0.2645009616508636,"score_spread":0.2405445389342407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}