{"id":"W2089283827","doi":"10.1371/journal.pmed.1001112","title":"Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies","year":2011,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Barts and The London School of Medicine and Dentistry; NIHR Cambridge Biomedical Research Centre; Erasmus Universitair Medisch Centrum Rotterdam; Institute of Genetics; Leibniz-Gemeinschaft; Incyte; Uppsala Universitet; Medical Research Council; National Institutes of Health; Hjartavernd; Universität Ulm; Academy of Finland; Centre National de la Recherche Scientifique; Terveyden ja hyvinvoinnin laitos; Syddansk Universitet; Newcastle University; Universitair Medisch Centrum Groningen; British Heart Foundation; Háskóli Íslands; Landspítali Háskólasjúkrahús; Kuopion Yliopistollinen Sairaala; Lunds Universitet; Rijksuniversiteit Groningen; Institut National de la Santé et de la Recherche Médicale; Norges Teknisk-Naturvitenskapelige Universitet; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Broad Institute; McGill University; University of Dundee; University of Oxford; Massachusetts Institute of Technology; Centre Hospitalier Universitaire de Poitiers; University of Exeter; Johns Hopkins University; Faculty of Medicine, McGill University; Helsingin Yliopisto; GlaxoSmithKline; Imperial College London; National Institute for Health and Care Research; University of North Carolina at Chapel Hill; Queen Mary University of London; Wellcome Trust; University of Southern California; University of Minnesota; Massachusetts General Hospital; Diabetes Research and Wellness Foundation; Brigham and Women's Hospital","keywords":"Mendelian randomization; Natriuretic peptide; Type 2 diabetes; Medicine; Diabetes mellitus; Internal medicine; Endocrinology; Causal inference; Randomization; Hormone; Population; Clinical trial; Bioinformatics; Biology; Genetics; Gene; Heart failure; Genetic variants; Pathology; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004491745,0.0001136409,0.0005620494,0.0001472642,0.00002750078,0.000001338666,0.00003088138,0.00004656091,0.0001002264],"category_scores_gemma":[0.001932936,0.00007940663,0.00001889225,0.0002609057,0.00003635756,0.0000835687,0.00002752842,0.00005985656,0.000003185615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008233658,"about_ca_system_score_gemma":0.00001577473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006322062,"about_ca_topic_score_gemma":0.0001188473,"domain_scores_codex":[0.9987709,0.0001119833,0.0004222553,0.0001728605,0.0004145516,0.0001074536],"domain_scores_gemma":[0.9988239,0.0003149476,0.0002581762,0.0001669944,0.0003841636,0.00005179708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001075011,0.0005729415,0.9759967,0.0003075696,0.001374509,0.000007291187,0.01438311,0.00000216995,0.004377285,0.00002118329,0.001345746,0.0005364896],"study_design_scores_gemma":[0.02317592,0.01178139,0.9394502,0.003314893,0.007389596,7.922361e-7,0.01058358,0.000681086,0.002922984,0.0004112016,0.00008868214,0.0001996794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952348,0.00279775,0.000006605356,0.0007361866,0.0001744657,0.0009045986,9.185982e-7,0.00002423125,0.0001203905],"genre_scores_gemma":[0.9982889,0.0008910008,0.0003773728,0.00005179934,0.00009429223,0.00001312262,0.00002611853,0.00001057806,0.0002468353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0365465,"threshold_uncertainty_score":0.3238108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09804568142012271,"score_gpt":0.3264028689710912,"score_spread":0.2283571875509685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}