{"id":"W2089283827","doi":"10.1371/journal.pmed.1001112","title":"Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies","year":2011,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Barts and The London School of Medicine and Dentistry; NIHR Cambridge Biomedical Research Centre; Erasmus Universitair Medisch Centrum Rotterdam; Institute of Genetics; Leibniz-Gemeinschaft; Incyte; Uppsala Universitet; Medical Research Council; National Institutes of Health; Hjartavernd; Universität Ulm; Academy of Finland; Centre National de la Recherche Scientifique; Terveyden ja hyvinvoinnin laitos; Syddansk Universitet; Newcastle University; Universitair Medisch Centrum Groningen; British Heart Foundation; Háskóli Íslands; Landspítali Háskólasjúkrahús; Kuopion Yliopistollinen Sairaala; Lunds Universitet; Rijksuniversiteit Groningen; Institut National de la Santé et de la Recherche Médicale; Norges Teknisk-Naturvitenskapelige Universitet; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Broad Institute; McGill University; University of Dundee; University of Oxford; Massachusetts Institute of Technology; Centre Hospitalier Universitaire de Poitiers; University of Exeter; Johns Hopkins University; Faculty of Medicine, McGill University; Helsingin Yliopisto; GlaxoSmithKline; Imperial College London; National Institute for Health and Care Research; University of North Carolina at Chapel Hill; Queen Mary University of London; Wellcome Trust; University of Southern California; University of Minnesota; Massachusetts General Hospital; Diabetes Research and Wellness Foundation; Brigham and Women's Hospital","keywords":"Mendelian randomization; Natriuretic peptide; Type 2 diabetes; Medicine; Diabetes mellitus; Internal medicine; Endocrinology; Causal inference; Randomization; Hormone; Population; Clinical trial; Bioinformatics; Biology; Genetics; Gene; Heart failure; Genetic variants; Pathology; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07482056,0.001684623,0.003976453,0.002321662,0.0007104111,0.002164345,0.002337059,0.002756173,0.003621001],"category_scores_gemma":[0.1421047,0.001140984,0.007894482,0.003442081,0.001624781,0.001117992,0.0009764439,0.001539189,0.0002755364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006807175,"about_ca_system_score_gemma":0.001020676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890077,"about_ca_topic_score_gemma":0.001321058,"domain_scores_codex":[0.8661989,0.1021489,0.009584884,0.01411994,0.006998374,0.0009489559],"domain_scores_gemma":[0.8763772,0.08811538,0.01517163,0.01676019,0.002844048,0.0007314974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03569446,0.0002338294,0.5596333,0.005399073,0.3373093,0.002329583,0.0005571891,0.003879968,0.003150755,0.00564101,0.002779092,0.04339239],"study_design_scores_gemma":[0.03467337,0.007212883,0.4222651,0.002731655,0.431084,0.00757871,0.0004308424,0.03711342,0.003086847,0.04206578,0.0113688,0.0003885498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7328001,0.104307,0.1468794,0.003179259,0.002551648,0.002251797,0.002777875,0.001031057,0.004221795],"genre_scores_gemma":[0.9765912,0.003991968,0.01664871,0.0008328301,0.0003093795,0.0007383073,0.0005619636,0.00008011505,0.0002456414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07482056,"threshold_uncertainty_score":0.3956937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09804568142012271,"score_gpt":0.3264028689710912,"score_spread":0.2283571875509685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}