{"id":"W2089290845","doi":"10.1158/0008-5472.can-07-5428","title":"Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Institute on Aging","keywords":"T790M; Cancer research; Gefitinib; Protein kinase B; Epidermal growth factor receptor; EGFR inhibitors; Erlotinib; PI3K/AKT/mTOR pathway; Kinase; Tyrosine kinase; Phosphorylation; Tyrosine-kinase inhibitor; Chemistry; Biology; Signal transduction; Pharmacology; Cancer; Cell biology; Medicine; Receptor; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007916401,0.0003111319,0.0003163564,0.000208159,0.0001069641,0.0002315005,0.000242234,0.0001800967,0.0009440982],"category_scores_gemma":[0.00006783524,0.0001058053,0.0002990356,0.0001818875,0.0001172258,0.000136706,0.0001682493,0.0005113914,0.0004465488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819384,"about_ca_system_score_gemma":0.0002477459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007432898,"about_ca_topic_score_gemma":0.001286237,"domain_scores_codex":[0.9998808,0.00001350226,0.00001140182,0.00001455838,0.00003360055,0.00004604565],"domain_scores_gemma":[0.9999554,0.000003225439,0.0000137759,0.000006492634,0.000005163758,0.0000158848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001687955,0.0002148516,0.0002281689,0.00003665281,0.00001835939,0.00007216757,0.00001355478,0.0003615871,0.9921889,0.0001752046,0.0003025094,0.006219294],"study_design_scores_gemma":[0.00008279667,0.001678303,0.004366856,0.000005416344,0.00002612179,0.000398269,0.0000189221,0.001347837,0.987699,0.00005993456,0.004309246,0.000007221539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955196,0.0008202453,0.0007845114,0.00008980749,0.00003135147,0.00004369436,0.0003760792,0.0002184426,0.002116275],"genre_scores_gemma":[0.9962596,0.000721298,0.0004762541,0.00004876457,0.000008745233,0.00002595074,0.0006600043,0.00002823251,0.001771269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009440982,"threshold_uncertainty_score":0.003158331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0647584607196473,"score_gpt":0.4074752702221794,"score_spread":0.3427168095025321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}