{"id":"W2089303433","doi":"10.1016/j.jaut.2015.01.009","title":"Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus","year":2015,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université Laval; University of Ottawa; Toronto Western Hospital","funders":"Canadian Institutes of Health Research","keywords":"Syk; B cell; Immunology; Signal transduction; Phenotype; breakpoint cluster region; Phosphorylation; Systemic lupus erythematosus; B-cell receptor; Apoptosis; Lupus erythematosus; Receptor; Cell; Biology; Antibody; Cell biology; Medicine; Internal medicine; Tyrosine kinase; Genetics; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000337219,0.0003575171,0.0003492396,0.0004100789,0.0001843225,0.0003850572,0.0001975548,0.0003991549,0.001170005],"category_scores_gemma":[0.000257955,0.000218106,0.0002979269,0.0002169123,0.0002970273,0.0001781634,0.0001979359,0.0007887825,0.0004505122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002935706,"about_ca_system_score_gemma":0.0001205176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000169472,"about_ca_topic_score_gemma":0.0001909772,"domain_scores_codex":[0.9996883,0.0000923163,0.00004594582,0.00003594504,0.00005229404,0.00008513778],"domain_scores_gemma":[0.9998081,0.00003596875,0.00004522417,0.00004141175,0.00001291187,0.00005644295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009478148,0.00005687049,0.001172209,0.00002116033,0.000008670105,0.0003986537,0.00002088074,0.00003641016,0.9961057,0.00004925322,0.00002882644,0.001153524],"study_design_scores_gemma":[0.0004531304,0.002509268,0.09965134,0.00002970846,0.0001375796,0.004710377,0.0002657296,0.001184083,0.8881904,0.0004127509,0.002435089,0.00002053163],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989558,0.0003180447,0.0002080962,0.00002475243,0.00002101497,0.000004973792,0.00004238276,0.00002332165,0.000401635],"genre_scores_gemma":[0.999256,0.00015501,0.0001086177,0.00002714041,0.00001192732,0.000007839512,0.00005373283,0.000007884913,0.0003718768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170005,"threshold_uncertainty_score":0.003914058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02566417560397861,"score_gpt":0.229603224247807,"score_spread":0.2039390486438284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}