{"id":"W2089303591","doi":"10.1124/jpet.111.182634","title":"Decreased Cytochrome c Oxidase IV Expression Reduces Steroidogenesis","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; University of Alberta; Cancer Research Institute","keywords":"Cholesterol side-chain cleavage enzyme; Pregnenolone; Dehydroepiandrosterone; Chemistry; Inner mitochondrial membrane; Gene knockdown; Cytochrome P450; Enzyme; Cytochrome c oxidase; Internal medicine; Mitochondrion; Endocrinology; Biochemistry; Hormone; Biology; Steroid; Apoptosis; Androgen; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002244988,0.0003727199,0.0005187329,0.0003327917,0.0003367296,0.0005911027,0.0004169569,0.0004907461,0.003898354],"category_scores_gemma":[0.0004013366,0.0003212742,0.0002705423,0.0002545806,0.0006019544,0.0002892745,0.0002026752,0.001248765,0.0005342639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006136666,"about_ca_system_score_gemma":0.0005266779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544299,"about_ca_topic_score_gemma":0.001787596,"domain_scores_codex":[0.9996889,0.00006024345,0.00002518362,0.00006116794,0.00005283707,0.0001118432],"domain_scores_gemma":[0.999626,0.0000636331,0.00008228604,0.00005549342,0.00004137665,0.0001311095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001378619,0.0001539698,0.0002239407,0.00003155318,0.00001649105,0.00003473694,0.00001492452,0.00003970834,0.9964359,0.0001849973,0.000126415,0.001358746],"study_design_scores_gemma":[0.0001044532,0.0007173803,0.002459123,0.00000551312,0.00003217509,0.000133973,0.0000491604,0.0004126298,0.9944816,0.0001016761,0.001497406,0.0000050023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936957,0.001198374,0.002495378,0.0005328452,0.0002222043,0.00003142823,0.0003513032,0.0001620355,0.001310737],"genre_scores_gemma":[0.9911792,0.0006012375,0.001035074,0.00008660532,0.00003754149,0.00003234831,0.0004439966,0.00004859944,0.0065354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003898354,"threshold_uncertainty_score":0.01304132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02399155623945905,"score_gpt":0.3046854051329406,"score_spread":0.2806938488934816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}