{"id":"W2089316366","doi":"10.4161/rna.23686","title":"HMGA1 directly interacts with TAR to modulate basal and Tat-dependent HIV transcription","year":2013,"lang":"en","type":"article","venue":"RNA Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"George Washington University","keywords":"Transactivation; Transcription (linguistics); HIV Long Terminal Repeat; RNA polymerase II; General transcription factor; Transcription factor II D; Molecular biology; Transcription factor; Biology; Gene knockdown; Transcription factor II F; RNA polymerase II holoenzyme; RNA; Response element; Promoter; Chemistry; Cell biology; RNA polymerase; Long terminal repeat; Transcriptional regulation; Gene expression; Biochemistry; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00009163952,0.0001626443,0.0002249325,0.000110273,0.00009782735,0.00001755993,0.0001086284,0.0001477182,0.001103161],"category_scores_gemma":[0.00002172878,0.0001083123,0.0000306981,0.00006279839,0.0001364397,0.00008007013,0.00004709599,0.0001759006,0.004139767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004403479,"about_ca_system_score_gemma":0.00002655934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008149793,"about_ca_topic_score_gemma":0.0002399724,"domain_scores_codex":[0.9988604,0.0001872895,0.0001504747,0.0003353668,0.00002088453,0.0004456523],"domain_scores_gemma":[0.9995942,0.0000638448,0.00003208559,0.0001726826,0.00005557333,0.00008165833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002895294,0.0001041141,0.004209875,0.00000669505,0.0002067403,0.00001338268,0.0004041577,0.000002860629,0.9687707,0.0001773174,0.002259386,0.02355518],"study_design_scores_gemma":[0.008688166,0.006524152,0.1712652,0.00008523485,0.0001000487,0.0003410378,0.0004475531,0.00003425726,0.7255474,0.001169706,0.08499573,0.0008015448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99493,0.000828244,0.0004650839,0.001904951,0.0001805358,0.0004590792,0.00008169153,0.00004941008,0.001100975],"genre_scores_gemma":[0.9959742,0.00009225709,0.0002354853,0.0003127336,0.00002124121,0.0001191186,0.0002257117,0.00001273234,0.003006522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2432234,"threshold_uncertainty_score":0.99981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027413279406875,"score_gpt":0.2397006567538564,"score_spread":0.2294265239597877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}