{"id":"W2089438710","doi":"10.1042/bj20130317","title":"Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance","year":2013,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Aminoglycoside; Antibiotics; Enzyme; Phosphotransferases; Biochemistry; Biology; Escherichia coli; Antibiotic resistance; Microbiology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009015617,0.0003955786,0.000310292,0.0001985366,0.00009228419,0.0003125815,0.0002602234,0.0002219664,0.0007185381],"category_scores_gemma":[0.000101717,0.0001244936,0.0002193527,0.0001793018,0.0001565772,0.0001748307,0.0001349058,0.0004478667,0.0002247656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900783,"about_ca_system_score_gemma":0.0002778055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005408136,"about_ca_topic_score_gemma":0.001290049,"domain_scores_codex":[0.9999279,0.000009219073,0.000006131897,0.00001499272,0.000023658,0.00001825211],"domain_scores_gemma":[0.9999564,0.000005672414,0.00001718343,0.000003462983,0.000007508574,0.000009792223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000133704,0.00008806064,0.0001039012,0.00005643438,0.000008645698,0.00005718533,0.00001024197,0.0021692,0.9924636,0.0002843996,0.00007804613,0.004546646],"study_design_scores_gemma":[0.0001045181,0.00167408,0.001604124,0.000008944663,0.00003553748,0.0002444097,0.00002250353,0.004703681,0.986204,0.0001082078,0.005279137,0.00001083225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872908,0.003019423,0.004942339,0.0001191913,0.00003735508,0.0001074885,0.0003468255,0.0001425519,0.003994106],"genre_scores_gemma":[0.992119,0.002192135,0.003787016,0.00004934475,0.000007513797,0.00003396212,0.0003525786,0.00001724795,0.001441191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007185381,"threshold_uncertainty_score":0.002830267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007570565364025067,"score_gpt":0.2300865893466583,"score_spread":0.2225160239826333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}