{"id":"W2089442372","doi":"10.1016/j.imlet.2005.03.003","title":"The C3a receptor antagonist SB 290157 has agonist activity","year":2005,"lang":"en","type":"article","venue":"Immunology Letters","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Anaphylatoxin; Agonist; Receptor; Antagonist; Pharmacology; Regulator; Transfection; Biology; Cell biology; Chemistry; Immune system; Immunology; Biochemistry; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930078,0.0004247291,0.0006812266,0.000165335,0.0002543586,0.0004605502,0.0003779455,0.0004968908,0.00587182],"category_scores_gemma":[0.0002765842,0.0001960764,0.0003270519,0.0001386353,0.0002705759,0.00016934,0.0002356172,0.001129276,0.003100593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374382,"about_ca_system_score_gemma":0.0005522691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000665649,"about_ca_topic_score_gemma":0.001143798,"domain_scores_codex":[0.9998542,0.00003866385,0.000008596406,0.00001358318,0.00003440917,0.00005047182],"domain_scores_gemma":[0.9998801,0.00002911104,0.00001558389,0.00001654495,0.00001625378,0.00004238262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002450134,0.0002342523,0.0003139154,0.0001728949,0.00004135982,0.0003101135,0.00003145877,0.000158449,0.9674769,0.0006788776,0.001434502,0.02669709],"study_design_scores_gemma":[0.001180951,0.008341203,0.01314884,0.00007425639,0.0001873887,0.003602975,0.0001132107,0.001366041,0.9322851,0.0005307009,0.0391313,0.00003804854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476284,0.02110905,0.002834952,0.001418517,0.0003904654,0.0001215173,0.0007932226,0.0002110616,0.02549284],"genre_scores_gemma":[0.9748806,0.008649154,0.002050156,0.0007274754,0.0001798625,0.00006873829,0.001741143,0.00003523491,0.01166757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00587182,"threshold_uncertainty_score":0.01964325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763755271941185,"score_gpt":0.2456370604766785,"score_spread":0.2279995077572666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}