{"id":"W2089442495","doi":"10.1006/bbrc.2001.4394","title":"Mutations of the C-Terminal End of Cathepsin K Affect Proenzyme Secretion and Intracellular Maturation","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Secretion; Brefeldin A; Intracellular; Cathepsin D; Tunicamycin; Cathepsin E; Cathepsin O; Cathepsin C; Cathepsin; Cathepsin L; Cathepsin L1; Cathepsin B; Biology; Cathepsin H; Cathepsin A; Secretory pathway; Cathepsin S; Lysosome; Biochemistry; Cell biology; Golgi apparatus; Endoplasmic reticulum; Enzyme; Unfolded protein response","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002937753,0.001006029,0.0005379925,0.0005635375,0.0004251267,0.0006939327,0.0005781344,0.00154507,0.002049973],"category_scores_gemma":[0.0009558912,0.0004799837,0.0009793073,0.0003666273,0.001200641,0.0004972592,0.00067601,0.00121177,0.001295708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008171456,"about_ca_system_score_gemma":0.0004367012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161037,"about_ca_topic_score_gemma":0.0008981567,"domain_scores_codex":[0.9994611,0.000119211,0.0001609353,0.00007068912,0.0001033197,0.00008468283],"domain_scores_gemma":[0.9986832,0.0003999605,0.0004137744,0.0001640318,0.0000777173,0.0002613189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008332824,0.00007985639,0.0005794658,0.00005644103,0.00005220957,0.001635846,0.00005356837,0.0005993837,0.9940356,0.0004866892,0.0001131525,0.001474441],"study_design_scores_gemma":[0.0001595529,0.000303472,0.004180544,0.00001736041,0.00009922684,0.004648669,0.00006897558,0.002896666,0.9848106,0.0002528948,0.00252056,0.00004158825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937671,0.0005100726,0.003413137,0.0001785064,0.000128401,0.00004428771,0.0005117674,0.0001156171,0.001331104],"genre_scores_gemma":[0.9968414,0.0002426404,0.001310435,0.00006909468,0.00002451869,0.00001903708,0.0002731198,0.00006194276,0.001157766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049973,"threshold_uncertainty_score":0.006857872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04552700040727629,"score_gpt":0.3466455728807227,"score_spread":0.3011185724734464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}