{"id":"W2089447567","doi":"10.1186/ar2262","title":"Altered expression and production of leptin is responsible for abnormal cell markers in subchondral osteoblasts from osteoarthritic patients","year":2007,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"National Institutes of Health; Hungarian Scientific Research Fund","keywords":"Subchondral bone; Rheumatology; Leptin; Medicine; Internal medicine; Osteoarthritis; Endocrinology; Pathology; Articular cartilage; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001365945,0.0002198186,0.0004121451,0.0005367558,0.0001627867,0.00003360949,0.0001009348,0.0001708961,0.0001462468],"category_scores_gemma":[0.0002267119,0.0002093854,0.00009969789,0.0003607585,0.0002073844,0.0002984656,0.00005926612,0.0003007252,0.00001368845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000824228,"about_ca_system_score_gemma":0.0001639478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001189686,"about_ca_topic_score_gemma":0.0006376787,"domain_scores_codex":[0.9972094,0.0002299928,0.0005309979,0.0005810281,0.0007009972,0.0007475351],"domain_scores_gemma":[0.9984,0.0004711007,0.00009623373,0.0003910583,0.0004020194,0.0002395674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01173351,0.0005424116,0.02390824,0.0000475726,0.000009914967,0.00002922847,0.001603306,1.705526e-7,0.7018077,0.00001817434,0.0009145709,0.2593852],"study_design_scores_gemma":[0.02420516,0.01086613,0.02225635,0.0009938658,0.000005805898,0.00001058893,0.0009905959,0.000004051528,0.9364503,0.0008020492,0.00322357,0.0001915476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918181,0.004371246,0.00001376306,0.000363653,0.0003064665,0.002622947,0.00007459452,0.00002908869,0.0004001113],"genre_scores_gemma":[0.9919919,0.003679683,0.002916519,0.00008043968,0.000190752,0.0001600451,0.0001500856,0.00005079954,0.0007797992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2591937,"threshold_uncertainty_score":0.8538487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088318788180307,"score_gpt":0.3194738396177192,"score_spread":0.2885906517359162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}