{"id":"W2089465207","doi":"10.1523/jneurosci.4974-09.2010","title":"Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Metabotropic glutamate receptor 5; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor; Medium spiny neuron; Huntington's disease; Cell biology; Metabotropic glutamate receptor 3; Neuroscience; Glutamate receptor; MAPK/ERK pathway; Metabotropic glutamate receptor 4; Neurodegeneration; Huntingtin; Metabotropic glutamate receptor 6; Biology; Metabotropic glutamate receptor 7; Chemistry; Striatum; Receptor; Signal transduction; Internal medicine; Medicine; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931021,0.001107526,0.0005465968,0.001190861,0.0003651024,0.0004656496,0.0004584977,0.00138765,0.002956356],"category_scores_gemma":[0.0001350556,0.0004381022,0.0004898188,0.000469787,0.0005757185,0.0004687329,0.0003647248,0.001350425,0.0008075705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007344658,"about_ca_system_score_gemma":0.0002531626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285654,"about_ca_topic_score_gemma":0.00202564,"domain_scores_codex":[0.9996758,0.00003722499,0.00004504885,0.000100999,0.00007746229,0.00006350278],"domain_scores_gemma":[0.9997745,0.00002029703,0.00007636451,0.00001918712,0.00001693047,0.00009266802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000496596,0.0002306241,0.0004617637,0.00004897657,0.00002151089,0.000474199,0.00004823699,0.00007721168,0.99676,0.0001902893,0.0001321064,0.001058622],"study_design_scores_gemma":[0.0006226712,0.004497008,0.0699731,0.0001071275,0.0003066548,0.006020041,0.0003184977,0.003436594,0.9001179,0.0007656708,0.01377097,0.00006382905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992312,0.00148171,0.00174615,0.00029707,0.00005857493,0.0001223137,0.00206176,0.000236713,0.001683692],"genre_scores_gemma":[0.978238,0.002476781,0.004038218,0.0003316878,0.00003387338,0.000463105,0.003080476,0.0001019172,0.01123612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002956356,"threshold_uncertainty_score":0.00989002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04049112140438485,"score_gpt":0.2526369432727555,"score_spread":0.2121458218683706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}